biostudies-literatureUnknown70(1)Rahim MA<i>Staphylococcus aureus</i> is currently a significant multidrug-resistant bacterium, causing severe healthcare-associated and community-acquired infections worldwide. The current antibiotic regimen against this pathogen is becoming ineffective due to resistance, in addition, they disrupt the normal microbiota. It highlights the urgent need for a pathogen-specific drug with high antibacterial efficacy against <i>S. aureus</i>. α-Viniferin, a bioactive phytochemical compound, has been reported to have excellent anti-<i>Staphylococcus</i> efficacy as a topical agent. However, so far, there were no clinical trials that have been conducted to elucidate its efficacy. The present study aimed to investigate the antibacterial efficacy of α-viniferin against <i>S. aureus</i> in a ten-day clinical Polish journal of microbiology117-130https://www.ebi.ac.uk/biostudies/studies/S-EPMC8008767biostudies-literatureA Clinical Trial to Evaluate the Efficacy of α-Viniferin in <i>Staphylococcus aureus</i> - Specific Decolonization without Depleting the Normal Microbiota of Nares.PMC8008767Kim SSong HYLee SSeo HJeong YKRahim MATajdozian HKim MfalseA Clinical Trial to Evaluate the Efficacy of α-Viniferin in <i>Staphylococcus aureus</i> - Specific Decolonization without Depleting the Normal Microbiota of Nares.<i>Staphylococcus aureus</i> is currently a significant multidrug-resistant bacterium, causing severe healthcare-associated and community-acquired infections worldwide. The current antibiotic regimen against this pathogen is becoming ineffective due to resistance, in addition, they disrupt the normal microbiota. It highlights the urgent need for a pathogen-specific drug with high antibacterial efficacy against <i>S. aureus</i>. α-Viniferin, a bioactive phytochemical compound, has been reported to have excellent anti-<i>Staphylococcus</i> efficacy as a topical agent. However, so far, there were no clinical trials that have been conducted to elucidate its efficacy. The present study aimed to investigate the antibacterial efficacy of α-viniferin against <i>S. aureus</i> in a ten-day clinical 2021-01-01T00:00:00Z2021 Mar2025-04-18T16:51:45.589Z2022-02-11T04:05:42.775ZS-EPMC80087673381553310.33073/pjm-2021-011