{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Raeder SB"],"pubmed_abstract":["Antimicrobial resistance is an increasing threat to global health and challenges the way we treat infections. Peptides containing the PCNA interacting motif APIM (APIM-peptides) were recently shown to bind to the bacterial PCNA homolog, the beta (β)-clamp, and to have both antibacterial and anti-mutagenic activities. In this study we explore the antibacterial effects of these peptides on <i>Staphylococcus epidermidis</i>, a bacterial species commonly found in prosthetic joint infections (PJI). Drug-resistant bacterial isolates from PJIs often lead to difficult-to-treat chronic infections. We show that APIM-peptides have a rapid bactericidal effect which when used at sublethal levels also increase the efficacy of gentamicin. In addition, APIM-peptides reduce development and eliminate alread"],"journal":["Frontiers in microbiology"],"pagination":["631557"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8009970"],"repository":["biostudies-literature"],"pubmed_title":["Novel Peptides Targeting the β-Clamp Rapidly Kill Planktonic and Biofilm <i>Staphylococcus epidermidis</i> Both <i>in vitro</i> and <i>in vivo</i>."],"pmcid":["PMC8009970"],"pubmed_authors":["Bergh K","Witso E","Nepal A","Otterlei M","Sandbakken ET","Loseth K","Raeder SB"],"additional_accession":[]},"is_claimable":false,"name":"Novel Peptides Targeting the β-Clamp Rapidly Kill Planktonic and Biofilm <i>Staphylococcus epidermidis</i> Both <i>in vitro</i> and <i>in vivo</i>.","description":"Antimicrobial resistance is an increasing threat to global health and challenges the way we treat infections. Peptides containing the PCNA interacting motif APIM (APIM-peptides) were recently shown to bind to the bacterial PCNA homolog, the beta (β)-clamp, and to have both antibacterial and anti-mutagenic activities. In this study we explore the antibacterial effects of these peptides on <i>Staphylococcus epidermidis</i>, a bacterial species commonly found in prosthetic joint infections (PJI). Drug-resistant bacterial isolates from PJIs often lead to difficult-to-treat chronic infections. We show that APIM-peptides have a rapid bactericidal effect which when used at sublethal levels also increase the efficacy of gentamicin. In addition, APIM-peptides reduce development and eliminate alread","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-04T18:37:47.616Z","creation":"2022-02-09T12:46:49.952Z"},"accession":"S-EPMC8009970","cross_references":{"pubmed":["33815313"],"doi":["10.3389/fmicb.2021.631557"]}}