biostudies-literatureGiri VKNational Center for Advancing Translational SciencesNCATS NIH HHSNIA NIH HHSNational Heart, Lung, and Blood InstituteNHLBI NIH HHSNational Cancer InstituteNCI NIH HHSAmerican Society of Hematology262.e1-262.e11https://www.ebi.ac.uk/biostudies/studies/S-EPMC8010223biostudies-literatureUnknown27(3)Bloodstream infections (BSIs) occur in 20% to 45% of inpatient autologous and allogeneic hematopoietic cell transplant (HCT) patients. Daily bathing with the antiseptic chlorhexidine gluconate (CHG) has been shown to reduce the incidence of BSIs in critically ill patients, although very few studies include HCT patients or have evaluated the impact of compliance on effectiveness. We conducted a prospective cohort study with historical controls to assess the impact of CHG bathing on the rate of BSIs and gut microbiota composition among adults undergoing inpatient HCT at the Duke University Medical Center. We present 1 year of data without CHG bathing (2016) and 2 years of data when CHG was used on the HCT unit (2017 and 2018). Because not all patients adhered to CHG, patients were grouped inTransplantation and cellular therapyChlorhexidine Gluconate Bathing Reduces the Incidence of Bloodstream Infections in Adults Undergoing Inpatient Hematopoietic Cell Transplantation.PMC8010223P30 CA008748UL1 TR002553R21 AG066388K08 HL143189KL2 TR001115Gasparetto CJGiri VKMessina JAAndermann TMMa Lvan den Brink MRMRen YGomes ALCChao NJKegerreis KGChoi TJung SHAllen DHLong GDSung ADBohannon LMLopez RDMowery YMPeled JUSarantopoulos SGreenberg MMatthews ASaullo JLHorwitz MELassiter MSito ELobaugh-Jin ERizzieri DAfalseChlorhexidine Gluconate Bathing Reduces the Incidence of Bloodstream Infections in Adults Undergoing Inpatient Hematopoietic Cell Transplantation.Bloodstream infections (BSIs) occur in 20% to 45% of inpatient autologous and allogeneic hematopoietic cell transplant (HCT) patients. Daily bathing with the antiseptic chlorhexidine gluconate (CHG) has been shown to reduce the incidence of BSIs in critically ill patients, although very few studies include HCT patients or have evaluated the impact of compliance on effectiveness. We conducted a prospective cohort study with historical controls to assess the impact of CHG bathing on the rate of BSIs and gut microbiota composition among adults undergoing inpatient HCT at the Duke University Medical Center. We present 1 year of data without CHG bathing (2016) and 2 years of data when CHG was used on the HCT unit (2017 and 2018). Because not all patients adhered to CHG, patients were grouped in2021-01-01T00:00:00Z2021 Mar2025-04-04T10:17:10.465Z2025-04-04T10:17:10.465ZS-EPMC80102233378153210.1016/j.jtct.2021.01.004