{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["118(6)"],"submitter":["Zhang W"],"pubmed_abstract":["Gene retroposition is known to contribute to patterns of gene evolution and adaptations. However, possible negative effects of gene retroposition remain largely unexplored since most previous studies have focused on between-species comparisons where negatively selected copies are mostly not observed, as they are quickly lost from populations. Here, we show for natural house mouse populations that the primary rate of retroposition is orders of magnitude higher than the long-term rate. Comparisons with single-nucleotide polymorphism distribution patterns in the same populations show that most retroposition events are deleterious. Transcriptomic profiling analysis shows that new retroposed copies become easily subject to transcription and have an influence on the expression levels of their pa"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["e2013043118"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8017666"],"repository":["biostudies-literature"],"pubmed_title":["The mutational load in natural populations is significantly affected by high primary rates of retroposition."],"pmcid":["PMC8017666"],"pubmed_authors":["Zhang W","Zhang YE","Tautz D","Ullrich K","Xie C"],"additional_accession":[]},"is_claimable":false,"name":"The mutational load in natural populations is significantly affected by high primary rates of retroposition.","description":"Gene retroposition is known to contribute to patterns of gene evolution and adaptations. However, possible negative effects of gene retroposition remain largely unexplored since most previous studies have focused on between-species comparisons where negatively selected copies are mostly not observed, as they are quickly lost from populations. Here, we show for natural house mouse populations that the primary rate of retroposition is orders of magnitude higher than the long-term rate. Comparisons with single-nucleotide polymorphism distribution patterns in the same populations show that most retroposition events are deleterious. Transcriptomic profiling analysis shows that new retroposed copies become easily subject to transcription and have an influence on the expression levels of their pa","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2026-04-17T23:39:24.948Z","creation":"2022-02-09T16:03:08.016Z"},"accession":"S-EPMC8017666","cross_references":{"pubmed":["33526666"],"doi":["10.1073/pnas.2013043118"]}}