biostudies-literatureZhou Xthe Beijing Municipal Science &amp; Technology commission national key research and development plan matching project599-605https://www.ebi.ac.uk/biostudies/studies/S-EPMC8018348biostudies-literatureUnknown43(1)The serum intact parathyroid hormone (iPTH) is associated with the prognosis of hemodialysis (HD) patients, however, its optimal range for reducing mortality remains inconsistent. We designed a prospective cohort study of 346 incident HD patients to assess the association between different serum iPTH level and mortality. According to the Kidney Disease Outcomes Quality Initiative (K/DOQI) international guidelines (2003), we divided patients into three groups (iPTH < 150 pg/mL, 150-300 pg/mL and >300 pg/mL). During the median follow-up of 58 months, 157 patients (45.38%) died. Multivariate Cox regression analysis showed that iPTH < 150 pg/mL and >300 pg/mL were associated with all-cause and cardiovascular mortality. Then, we performed a sensitivity analysis of patients divided into 6 serum Renal failureThe optimal range of serum intact parathyroid hormone for a lower risk of mortality in the incident hemodialysis patients.PMC8018348Z161100002616005Guo YLuo YZhou XfalseThe optimal range of serum intact parathyroid hormone for a lower risk of mortality in the incident hemodialysis patients.The serum intact parathyroid hormone (iPTH) is associated with the prognosis of hemodialysis (HD) patients, however, its optimal range for reducing mortality remains inconsistent. We designed a prospective cohort study of 346 incident HD patients to assess the association between different serum iPTH level and mortality. According to the Kidney Disease Outcomes Quality Initiative (K/DOQI) international guidelines (2003), we divided patients into three groups (iPTH < 150 pg/mL, 150-300 pg/mL and >300 pg/mL). During the median follow-up of 58 months, 157 patients (45.38%) died. Multivariate Cox regression analysis showed that iPTH < 150 pg/mL and >300 pg/mL were associated with all-cause and cardiovascular mortality. Then, we performed a sensitivity analysis of patients divided into 6 serum 2021-01-01T00:00:00Z2021 Dec2025-04-04T12:34:07.686Z2025-04-04T12:34:07.686ZS-EPMC80183483378117110.1080/0886022X.2021.1903927