{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Raboso-Gallego J"],"funding":["NCI NIH HHS"],"pagination":["1741-1753"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8020264"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["137(13)"],"pubmed_abstract":["Diffuse large B-cell lymphomas (DLBCLs) are clinically and genetically heterogeneous tumors. Deregulation of diverse biological processes specific to B cells, such as B-cell receptor (BCR) signaling and motility regulation, contribute to lymphomagenesis. Human germinal center associated lymphoma (HGAL) is a B-cell-specific adaptor protein controlling BCR signaling and B lymphocyte motility. In normal B cells, it is expressed in germinal center (GC) B lymphocytes and promptly downregulated upon further differentiation. The majority of DLBCL tumors, primarily GC B-cell types, but also activated types, express HGAL. To investigate the consequences of constitutive expression of HGAL in vivo, we generated mice that conditionally express human HGAL at different stages of hematopoietic developmen"],"journal":["Blood"],"pubmed_title":["Conditional expression of HGAL leads to the development of diffuse large B-cell lymphoma in mice."],"pmcid":["PMC8020264"],"funding_grant_id":["R01 CA233945"],"pubmed_authors":["Alonso-Lopez D","Raboso-Gallego J","Blanco O","Dominguez V","Casado-Garcia A","Pintado B","Lossos IS","Sanchez-Garcia I","Gentles AJ","Zhao S","Jiang X","Vicente-Duenas C","Natkunam Y","Isidro-Hernandez M","De Las Rivas J"],"additional_accession":[]},"is_claimable":false,"name":"Conditional expression of HGAL leads to the development of diffuse large B-cell lymphoma in mice.","description":"Diffuse large B-cell lymphomas (DLBCLs) are clinically and genetically heterogeneous tumors. Deregulation of diverse biological processes specific to B cells, such as B-cell receptor (BCR) signaling and motility regulation, contribute to lymphomagenesis. Human germinal center associated lymphoma (HGAL) is a B-cell-specific adaptor protein controlling BCR signaling and B lymphocyte motility. In normal B cells, it is expressed in germinal center (GC) B lymphocytes and promptly downregulated upon further differentiation. The majority of DLBCL tumors, primarily GC B-cell types, but also activated types, express HGAL. To investigate the consequences of constitutive expression of HGAL in vivo, we generated mice that conditionally express human HGAL at different stages of hematopoietic developmen","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2026-05-02T22:45:48.614Z","creation":"2025-02-18T23:36:35.12Z"},"accession":"S-EPMC8020264","cross_references":{"pubmed":["33024996"],"doi":["10.1182/blood.2020004996"]}}