{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bhatt AB"],"funding":["NCI","NCI NIH HHS","NIGMS NIH HHS"],"pagination":["101046"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8020482"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(6)"],"pubmed_abstract":["The epithelial to mesenchymal transition (EMT) is characterized by a loss of cell polarity, a decrease in the epithelial cell marker E-cadherin, and an increase in mesenchymal markers including the zinc-finger E-box binding homeobox (ZEB1). The EMT is also associated with an increase in cell migration and anchorage-independent growth. Induction of a reversal of the EMT, a mesenchymal to epithelial transition (MET), is an emerging strategy being explored to attenuate the metastatic potential of aggressive cancer types, such as triple-negative breast cancers (TNBCs) and tamoxifen-resistant (TAMR) ER-positive breast cancers, which have a mesenchymal phenotype. Patients with these aggressive cancers have poor prognoses, quick relapse, and resistance to most chemotherapeutic drugs. Overexpressi"],"journal":["Translational oncology"],"pubmed_title":["Diverse and converging roles of ERK1/2 and ERK5 pathways on mesenchymal to epithelial transition in breast cancer."],"pmcid":["PMC8020482"],"funding_grant_id":["R15 CA176496","U54 GM104940"],"pubmed_authors":["Lexner E","Miele L","Burow ME","Flaherty PT","Ucar DA","Matossian MD","Bhatt AB","Wright TD","Chakrabarty S","Barnes V","Cavanaugh JE"],"additional_accession":[]},"is_claimable":false,"name":"Diverse and converging roles of ERK1/2 and ERK5 pathways on mesenchymal to epithelial transition in breast cancer.","description":"The epithelial to mesenchymal transition (EMT) is characterized by a loss of cell polarity, a decrease in the epithelial cell marker E-cadherin, and an increase in mesenchymal markers including the zinc-finger E-box binding homeobox (ZEB1). The EMT is also associated with an increase in cell migration and anchorage-independent growth. Induction of a reversal of the EMT, a mesenchymal to epithelial transition (MET), is an emerging strategy being explored to attenuate the metastatic potential of aggressive cancer types, such as triple-negative breast cancers (TNBCs) and tamoxifen-resistant (TAMR) ER-positive breast cancers, which have a mesenchymal phenotype. Patients with these aggressive cancers have poor prognoses, quick relapse, and resistance to most chemotherapeutic drugs. Overexpressi","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2026-05-10T02:40:55.99Z","creation":"2022-02-09T12:49:17.433Z"},"accession":"S-EPMC8020482","cross_references":{"pubmed":["33761370"],"doi":["10.1016/j.tranon.2021.101046"]}}