biostudies-literatureChen YNIMHD NIH HHSNCI NIH HHSNational Institutes of HealthNIGMS NIH HHSe367https://www.ebi.ac.uk/biostudies/studies/S-EPMC8021541biostudies-literatureUnknown11(4)Lung cancer remains a major threat to human health. Low dose CT scan (LDCT) has become the main method of early screening for lung cancer due to the low sensitivity of chest X-ray. However, LDCT not only has a high false positive rate, but also entails risks of overdiagnosis and cumulative radiation exposure. In addition, cumulative radiation by LDCT screening and subsequent follow-up can increase the risk of lung cancer. Many studies have shown that long noncoding RNAs (lncRNAs) remain stable in blood, and profiling of blood has the advantages of being noninvasive, readily accessible and inexpensive. Serum or plasma assay of lncRNAs in blood can be used as a novel detection method to assist LDCT while improving the accuracy of early lung cancer screening. LncRNAs can participate in the reClinical and translational medicineThe function of LncRNAs and their role in the prediction, diagnosis, and prognosis of lung cancer.PMC8021541R01 CA223490P30 GM114737P30GM114737U54 MD007601P20GM103466P20 GM103466U54MD007584R01CA223490U54MD007601U54 MD007584Chen YGuo RZitello EDeng YfalseThe function of LncRNAs and their role in the prediction, diagnosis, and prognosis of lung cancer.Lung cancer remains a major threat to human health. Low dose CT scan (LDCT) has become the main method of early screening for lung cancer due to the low sensitivity of chest X-ray. However, LDCT not only has a high false positive rate, but also entails risks of overdiagnosis and cumulative radiation exposure. In addition, cumulative radiation by LDCT screening and subsequent follow-up can increase the risk of lung cancer. Many studies have shown that long noncoding RNAs (lncRNAs) remain stable in blood, and profiling of blood has the advantages of being noninvasive, readily accessible and inexpensive. Serum or plasma assay of lncRNAs in blood can be used as a novel detection method to assist LDCT while improving the accuracy of early lung cancer screening. LncRNAs can participate in the re2021-01-01T00:00:00Z2021 Apr2026-05-08T03:21:18.239Z2026-05-01T03:05:38.091ZS-EPMC80215413393198010.1002/ctm2.367