{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cho HW"],"funding":["Ministry of Science and ICT","Research Resettlement Fund for the new faculty of Seoul National University","National Research Foundation of Korea"],"pagination":["209-218"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8024159"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["45(2)"],"pubmed_abstract":["<h4>Background</h4>This study aimed to assess the effects of sarcopenia and A Body Shape Index (ABSI) on cardiovascular disease (CVD) risk according to obesity phenotypes.<h4>Methods</h4>We used data from the National Health and Nutrition Examination Survey 1999 to 2012. A total of 25,270 adults were included and classified into the following groups: metabolically healthy normal weight (MHNW), metabolically healthy overweight/obese (MHO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy overweight/obese (MUO). Sarcopenia was defined as the appendicular skeletal mass index <7 kg/m2 in men and <5.5kg/m2 in women. A multivariate logistic regression analysis was performed to evaluate the odds ratio (OR) of sarcopenia and ABSI for CVD events according to the obesity phenotype.<h4>Results</h4>The MHNW participants with sarcopenia had higher risk for CVD than those without sarcopenia (OR, 2.69; 95% confidence interval [CI], 1.56 to 4.64). In the analysis with MHNW participants without sarcopenia as a reference, the participants with sarcopenia showed a higher OR for CVD than those without sarcopenia in both MHO (OR in participants without sarcopenia, 3.31; 95% CI, 1.94 to 5.64) (OR in participants with sarcopenia, 8.59; 95% CI, 2.63 to 28.04) and MUO participants (OR in participants without sarcopenia, 5.11; 95% CI, 3.21 to 8.15) (OR in participants with sarcopenia, 8.12; 95% CI, 4.04 to 16.32). Participants within the second and third tertiles of ABSI had higher ORs for CVDs than the counterpart of obesity phenotypes within the first tertile.<h4>Conclusion</h4>These results suggest that clinical approaches that consider muscle and body shape are required."],"journal":["Diabetes & metabolism journal"],"pubmed_title":["Effect of Sarcopenia and Body Shape on Cardiovascular Disease According to Obesity Phenotypes."],"pmcid":["PMC8024159"],"funding_grant_id":["2017R1D1A1B03029575"],"pubmed_authors":["Moon S","Cho HW","Ryu OH","Kang JG","Kim MK","Chung W"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Sarcopenia and Body Shape on Cardiovascular Disease According to Obesity Phenotypes.","description":"<h4>Background</h4>This study aimed to assess the effects of sarcopenia and A Body Shape Index (ABSI) on cardiovascular disease (CVD) risk according to obesity phenotypes.<h4>Methods</h4>We used data from the National Health and Nutrition Examination Survey 1999 to 2012. A total of 25,270 adults were included and classified into the following groups: metabolically healthy normal weight (MHNW), metabolically healthy overweight/obese (MHO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy overweight/obese (MUO). Sarcopenia was defined as the appendicular skeletal mass index <7 kg/m2 in men and <5.5kg/m2 in women. A multivariate logistic regression analysis was performed to evaluate the odds ratio (OR) of sarcopenia and ABSI for CVD events according to the obesity phenotype.<h4>Results</h4>The MHNW participants with sarcopenia had higher risk for CVD than those without sarcopenia (OR, 2.69; 95% confidence interval [CI], 1.56 to 4.64). In the analysis with MHNW participants without sarcopenia as a reference, the participants with sarcopenia showed a higher OR for CVD than those without sarcopenia in both MHO (OR in participants without sarcopenia, 3.31; 95% CI, 1.94 to 5.64) (OR in participants with sarcopenia, 8.59; 95% CI, 2.63 to 28.04) and MUO participants (OR in participants without sarcopenia, 5.11; 95% CI, 3.21 to 8.15) (OR in participants with sarcopenia, 8.12; 95% CI, 4.04 to 16.32). Participants within the second and third tertiles of ABSI had higher ORs for CVDs than the counterpart of obesity phenotypes within the first tertile.<h4>Conclusion</h4>These results suggest that clinical approaches that consider muscle and body shape are required.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2024-11-12T13:02:20.13Z","creation":"2022-02-11T11:00:14.588Z"},"accession":"S-EPMC8024159","cross_references":{"pubmed":["32662256"],"doi":["10.4093/dmj.2019.0223"]}}