{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cui M"],"funding":["Chinese Academy of Medical Sciences","National Natural Science Foundation of China"],"pagination":["613530"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8024581"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["Traditionally, immunoglobulin (Ig) was believed to be produced by only B-lineage cells. However, increasing evidence has revealed a high level of Ig expression in cancer cells, and this Ig is named cancer-derived Ig. Further studies have shown that cancer-derived Ig shares identical basic structures with B cell-derived Ig but exhibits several distinct characteristics, including restricted variable region sequences and aberrant glycosylation. In contrast to B cell-derived Ig, which functions as an antibody in the humoral immune response, cancer-derived Ig exerts profound protumorigenic effects <i>via</i> multiple mechanisms, including promoting the malignant behaviors of cancer cells, mediating tumor immune escape, inducing inflammation, and activating the aggregation of platelets. Importan"],"journal":["Frontiers in immunology"],"pubmed_title":["Immunoglobulin Expression in Cancer Cells and Its Critical Roles in Tumorigenesis."],"pmcid":["PMC8024581"],"funding_grant_id":["2018PT32014","81872501, 81673023, 82030044, 91642206"],"pubmed_authors":["Cui M","Qiu X","Huang J","Liu Q","Liao Q","Zhang S"],"additional_accession":[]},"is_claimable":false,"name":"Immunoglobulin Expression in Cancer Cells and Its Critical Roles in Tumorigenesis.","description":"Traditionally, immunoglobulin (Ig) was believed to be produced by only B-lineage cells. However, increasing evidence has revealed a high level of Ig expression in cancer cells, and this Ig is named cancer-derived Ig. Further studies have shown that cancer-derived Ig shares identical basic structures with B cell-derived Ig but exhibits several distinct characteristics, including restricted variable region sequences and aberrant glycosylation. In contrast to B cell-derived Ig, which functions as an antibody in the humoral immune response, cancer-derived Ig exerts profound protumorigenic effects <i>via</i> multiple mechanisms, including promoting the malignant behaviors of cancer cells, mediating tumor immune escape, inducing inflammation, and activating the aggregation of platelets. Importan","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-05-29T20:03:14.781Z","creation":"2025-05-29T20:03:14.781Z"},"accession":"S-EPMC8024581","cross_references":{"pubmed":["33841396"],"doi":["10.3389/fimmu.2021.613530"]}}