biostudies-literatureCui MChinese Academy of Medical SciencesNational Natural Science Foundation of China613530https://www.ebi.ac.uk/biostudies/studies/S-EPMC8024581biostudies-literatureUnknown12Traditionally, immunoglobulin (Ig) was believed to be produced by only B-lineage cells. However, increasing evidence has revealed a high level of Ig expression in cancer cells, and this Ig is named cancer-derived Ig. Further studies have shown that cancer-derived Ig shares identical basic structures with B cell-derived Ig but exhibits several distinct characteristics, including restricted variable region sequences and aberrant glycosylation. In contrast to B cell-derived Ig, which functions as an antibody in the humoral immune response, cancer-derived Ig exerts profound protumorigenic effects <i>via</i> multiple mechanisms, including promoting the malignant behaviors of cancer cells, mediating tumor immune escape, inducing inflammation, and activating the aggregation of platelets. ImportanFrontiers in immunologyImmunoglobulin Expression in Cancer Cells and Its Critical Roles in Tumorigenesis.PMC80245812018PT3201481872501, 81673023, 82030044, 91642206Cui MQiu XHuang JLiu QLiao QZhang SfalseImmunoglobulin Expression in Cancer Cells and Its Critical Roles in Tumorigenesis.Traditionally, immunoglobulin (Ig) was believed to be produced by only B-lineage cells. However, increasing evidence has revealed a high level of Ig expression in cancer cells, and this Ig is named cancer-derived Ig. Further studies have shown that cancer-derived Ig shares identical basic structures with B cell-derived Ig but exhibits several distinct characteristics, including restricted variable region sequences and aberrant glycosylation. In contrast to B cell-derived Ig, which functions as an antibody in the humoral immune response, cancer-derived Ig exerts profound protumorigenic effects <i>via</i> multiple mechanisms, including promoting the malignant behaviors of cancer cells, mediating tumor immune escape, inducing inflammation, and activating the aggregation of platelets. Importan2021-01-01T00:00:00Z20212025-05-29T20:03:14.781Z2025-05-29T20:03:14.781ZS-EPMC80245813384139610.3389/fimmu.2021.613530