{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Zhang Y"],"funding":["Key Technologies Research and Development Program"],"pubmed_abstract":["<h4>Background</h4>Dengue fever is a mosquito-borne febrile illness. Southeast Asia experienced severe dengue outbreaks in 2019, and over 1000 cases had been reported in Jiangxi, a previously known low-epidemic region in China. However, the emergence of a dengue virus epidemic in a non-epidemic region remains unclear.<h4>Methods</h4>We enrolled 154 dengue fever patients from four hospitals in Jiangxi, from April 2019 to September 2019. Real-time PCR, NS1 antigen rapid test, and IgM, IgG tests were performed, and 14 samples were outsourced to be sequenced metagenomically.<h4>Results</h4>Among the 154 cases, 42 were identified as imported and most of them returned from Cambodia. A total of 113 blood samples were obtained and 106 were identified as DENV-1, two as DENV-2, and five were negative through RT-PCR. All DENV-1 strains sequenced in this study were all classified to one cluster and owned a high similarity with a Cambodia strain isolated in 2019. The evolutionary relationships of amino acid were consistent with that of nucleotide genome result. The sequence-based findings of Jiangxi strains were consistent with epidemiological investigation.<h4>Conclusion</h4>Epidemiological analysis demonstrated that the emergence of dengue cases led to autochthonous transmission in several cities in Jiangxi, a low-epidemic region before. This study emphasized future prevention and control of dengue fever in both epidemic and non-epidemic regions."],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["638785"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8024628"],"repository":["biostudies-literature"],"pubmed_title":["Emergence and Autochthonous Transmission of Dengue Virus Type I in a Low-Epidemic Region in Southeast China."],"pmcid":["PMC8024628"],"pubmed_authors":["Peng X","Wu J","Ju W","Chen Q","Luo F","Chen H","Zhou Y","Wang J","Jiang N","Ai J","Wang L","Zhang W","Huang Y","Zhang Y","Wang S","Wang X","Rao J","Tu X"],"additional_accession":[]},"is_claimable":false,"name":"Emergence and Autochthonous Transmission of Dengue Virus Type I in a Low-Epidemic Region in Southeast China.","description":"<h4>Background</h4>Dengue fever is a mosquito-borne febrile illness. Southeast Asia experienced severe dengue outbreaks in 2019, and over 1000 cases had been reported in Jiangxi, a previously known low-epidemic region in China. However, the emergence of a dengue virus epidemic in a non-epidemic region remains unclear.<h4>Methods</h4>We enrolled 154 dengue fever patients from four hospitals in Jiangxi, from April 2019 to September 2019. Real-time PCR, NS1 antigen rapid test, and IgM, IgG tests were performed, and 14 samples were outsourced to be sequenced metagenomically.<h4>Results</h4>Among the 154 cases, 42 were identified as imported and most of them returned from Cambodia. A total of 113 blood samples were obtained and 106 were identified as DENV-1, two as DENV-2, and five were negative through RT-PCR. All DENV-1 strains sequenced in this study were all classified to one cluster and owned a high similarity with a Cambodia strain isolated in 2019. The evolutionary relationships of amino acid were consistent with that of nucleotide genome result. The sequence-based findings of Jiangxi strains were consistent with epidemiological investigation.<h4>Conclusion</h4>Epidemiological analysis demonstrated that the emergence of dengue cases led to autochthonous transmission in several cities in Jiangxi, a low-epidemic region before. This study emphasized future prevention and control of dengue fever in both epidemic and non-epidemic regions.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2024-11-15T01:05:17.951Z","creation":"2022-02-09T14:46:11.833Z"},"accession":"S-EPMC8024628","cross_references":{"pubmed":["33842388"],"doi":["10.3389/fcimb.2021.638785"]}}