{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alfaro E"],"funding":["Ministerio de Economía, Industria y Competitividad, Gobierno de España"],"pagination":["e51030"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8025030"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(4)"],"pubmed_abstract":["Cell division requires the regulation of karyokinesis and cytokinesis, which includes an essential role of the achromatic spindle. Although the functions of centrosomes are well characterised in somatic cells, their role during vertebrate spermatogenesis remains elusive. We have studied the dynamics of the meiotic centrosomes in male mouse during both meiotic divisions. Results show that meiotic centrosomes duplicate twice: first duplication occurs in the leptotene/zygotene transition, while the second occurs in interkinesis. The maturation of duplicated centrosomes during the early stages of prophase I and II are followed by their separation and migration to opposite poles to form bipolar spindles I and II. The study of the genetic mouse model Plk1(Δ/Δ) indicates a central role of Polo-li"],"journal":["EMBO reports"],"pubmed_title":["PLK1 regulates centrosome migration and spindle dynamics in male mouse meiosis."],"pmcid":["PMC8025030"],"funding_grant_id":["BFU2014‐53681‐P","RTI2018‐095582‐B‐I00","BFU2015‐71786‐REDT"],"pubmed_authors":["Alfaro E","Suja JA","Malumbres M","Gomez R","Lopez-Jimenez P","Gonzalez-Martinez J"],"additional_accession":[]},"is_claimable":false,"name":"PLK1 regulates centrosome migration and spindle dynamics in male mouse meiosis.","description":"Cell division requires the regulation of karyokinesis and cytokinesis, which includes an essential role of the achromatic spindle. Although the functions of centrosomes are well characterised in somatic cells, their role during vertebrate spermatogenesis remains elusive. We have studied the dynamics of the meiotic centrosomes in male mouse during both meiotic divisions. Results show that meiotic centrosomes duplicate twice: first duplication occurs in the leptotene/zygotene transition, while the second occurs in interkinesis. The maturation of duplicated centrosomes during the early stages of prophase I and II are followed by their separation and migration to opposite poles to form bipolar spindles I and II. The study of the genetic mouse model Plk1(Δ/Δ) indicates a central role of Polo-li","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-04T10:16:07.448Z","creation":"2025-04-04T10:16:07.448Z"},"accession":"S-EPMC8025030","cross_references":{"pubmed":["33615693"],"doi":["10.15252/embr.202051030"]}}