{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Garchow B"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","Thomas Jefferson University","NIAMS NIH HHS"],"pagination":["128-134"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8026684"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["133"],"pubmed_abstract":["Systemic lupus erythematosus (SLE, lupus) is a chronic autoimmune disease characterized by loss of peripheral tolerance to nuclear self-antigens. It is increasingly recognized that aberrant T cell metabolism is a critical mediator of SLE immunopathology. Hypoxia inducible factor 1⍺ (HIF-1α) is a key transcription factor that regulates T cell metabolism in response to immune stimuli. T cell activation induces HIF-1α expression and transcriptional activation of HIF-responsive genes. HypoxamiRs are a group of microRNAs sensitive to HIF-1α transcriptional regulation that function to fine-tune the HIF-driven transcriptional program. The 'master' hypoxamiR, miR-210 is transcriptionally regulated by HIF-1α and negatively regulates HIF-1α activity. Although a key role for HIF-1α in has been descri"],"journal":["Molecular immunology"],"pubmed_title":["HIF-1α and miR-210 differential and lineage-specific expression in systemic lupus erythematosus."],"pmcid":["PMC8026684"],"funding_grant_id":["R03 AR060988","R21 AR063416"],"pubmed_authors":["Kiriakidou M","Maque Acosta Y","Garchow B"],"additional_accession":[]},"is_claimable":false,"name":"HIF-1α and miR-210 differential and lineage-specific expression in systemic lupus erythematosus.","description":"Systemic lupus erythematosus (SLE, lupus) is a chronic autoimmune disease characterized by loss of peripheral tolerance to nuclear self-antigens. It is increasingly recognized that aberrant T cell metabolism is a critical mediator of SLE immunopathology. Hypoxia inducible factor 1⍺ (HIF-1α) is a key transcription factor that regulates T cell metabolism in response to immune stimuli. T cell activation induces HIF-1α expression and transcriptional activation of HIF-responsive genes. HypoxamiRs are a group of microRNAs sensitive to HIF-1α transcriptional regulation that function to fine-tune the HIF-driven transcriptional program. The 'master' hypoxamiR, miR-210 is transcriptionally regulated by HIF-1α and negatively regulates HIF-1α activity. Although a key role for HIF-1α in has been descri","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2025-04-27T01:39:44.537Z","creation":"2025-04-06T18:20:47.179Z"},"accession":"S-EPMC8026684","cross_references":{"pubmed":["33657462"],"doi":["10.1016/j.molimm.2021.02.019"]}}