biostudies-literatureGarchow BNational Institute of Arthritis and Musculoskeletal and Skin DiseasesThomas Jefferson UniversityNIAMS NIH HHS128-134https://www.ebi.ac.uk/biostudies/studies/S-EPMC8026684biostudies-literatureUnknown133Systemic lupus erythematosus (SLE, lupus) is a chronic autoimmune disease characterized by loss of peripheral tolerance to nuclear self-antigens. It is increasingly recognized that aberrant T cell metabolism is a critical mediator of SLE immunopathology. Hypoxia inducible factor 1⍺ (HIF-1α) is a key transcription factor that regulates T cell metabolism in response to immune stimuli. T cell activation induces HIF-1α expression and transcriptional activation of HIF-responsive genes. HypoxamiRs are a group of microRNAs sensitive to HIF-1α transcriptional regulation that function to fine-tune the HIF-driven transcriptional program. The 'master' hypoxamiR, miR-210 is transcriptionally regulated by HIF-1α and negatively regulates HIF-1α activity. Although a key role for HIF-1α in has been descriMolecular immunologyHIF-1α and miR-210 differential and lineage-specific expression in systemic lupus erythematosus.PMC8026684R03 AR060988R21 AR063416Kiriakidou MMaque Acosta YGarchow BfalseHIF-1α and miR-210 differential and lineage-specific expression in systemic lupus erythematosus.Systemic lupus erythematosus (SLE, lupus) is a chronic autoimmune disease characterized by loss of peripheral tolerance to nuclear self-antigens. It is increasingly recognized that aberrant T cell metabolism is a critical mediator of SLE immunopathology. Hypoxia inducible factor 1⍺ (HIF-1α) is a key transcription factor that regulates T cell metabolism in response to immune stimuli. T cell activation induces HIF-1α expression and transcriptional activation of HIF-responsive genes. HypoxamiRs are a group of microRNAs sensitive to HIF-1α transcriptional regulation that function to fine-tune the HIF-driven transcriptional program. The 'master' hypoxamiR, miR-210 is transcriptionally regulated by HIF-1α and negatively regulates HIF-1α activity. Although a key role for HIF-1α in has been descri2021-01-01T00:00:00Z2021 May2025-04-27T01:39:44.537Z2025-04-06T18:20:47.179ZS-EPMC80266843365746210.1016/j.molimm.2021.02.019