biostudies-literatureKamimura DJackson State UniversityNIDDK NIH HHSNational Institute of Diabetes and Digestive and Kidney DiseasesNHLBI NIH HHSNIMHD NIH HHSNational Institute of General Medical SciencesNIGMS NIH HHS901-911https://www.ebi.ac.uk/biostudies/studies/S-EPMC8026689biostudies-literatureUnknown96(4)<h4>Objective</h4>To examine associations between physical activity (PA), inflammation, coronary artery calcification (CAC), and incident coronary heart disease (CHD) in African Americans.<h4>Methods</h4>Among Jackson Heart Study participants without prevalent CHD at baseline (n=4295), we examined the relationships between PA and high-sensitivity C-reactive protein, the presence of CAC (Agatston score ≥100), and incident CHD. Based on the American Heart Association's Life's Simple 7 metrics, participants were classified as having poor, intermediate, or ideal PA.<h4>Results</h4>After adjustment for possible confounding factors, ideal PA was associated with lower high-sensitivity C-reactive protein levels (β, -0.15; 95% CI, -0.15 to -0.002) and a lower prevalence of CAC (odds ratio, 0.70; 95Mayo Clinic proceedingsPhysical Activity, Inflammation, Coronary Artery Calcification, and Incident Coronary Heart Disease in African Americans: Insights From the Jackson Heart Study.PMC8026689HHSN268201800015IHHSN268201800012CHHSN268201800011CP20 GM104357HHSN268201800013IU54 GM104940K08 DK099415HHSN268201800014CU54 GM115428Suzuki TGuild CSLoprinzi PDOshunbade AAHall JECorrea AKamimura DClark DCain-Shields LRAshley KEHall MEBlaha MJButler JNewton RfalsePhysical Activity, Inflammation, Coronary Artery Calcification, and Incident Coronary Heart Disease in African Americans: Insights From the Jackson Heart Study.<h4>Objective</h4>To examine associations between physical activity (PA), inflammation, coronary artery calcification (CAC), and incident coronary heart disease (CHD) in African Americans.<h4>Methods</h4>Among Jackson Heart Study participants without prevalent CHD at baseline (n=4295), we examined the relationships between PA and high-sensitivity C-reactive protein, the presence of CAC (Agatston score ≥100), and incident CHD. Based on the American Heart Association's Life's Simple 7 metrics, participants were classified as having poor, intermediate, or ideal PA.<h4>Results</h4>After adjustment for possible confounding factors, ideal PA was associated with lower high-sensitivity C-reactive protein levels (β, -0.15; 95% CI, -0.15 to -0.002) and a lower prevalence of CAC (odds ratio, 0.70; 952021-01-01T00:00:00Z2021 Apr2025-04-29T11:30:41.939Z2025-04-06T19:55:11.496ZS-EPMC80266893371460410.1016/j.mayocp.2020.09.042