biostudies-literatureUnknown2021Saxena SDST-CSRI, OPERA, and the Centre for Human Disease ResearchA recent study showed the association of minor alleles of <i>rs2228611</i> (T allele) and <i>rs2114724</i> (T allele) of <i>DNMT1</i> with schizophrenia (SZ) and suggested their effects on splicing of the transcripts. We performed a replication study using 310 controls and 304 SZ patients and confirmed the association of the homozygous minor allele genotypes with SZ (<i>P</i> = 0.04 for <i>rs2114724</i> and <i>P</i> = 0.007 for rs<i>2228611</i>). This significant association persisted after Bonferroni correction when the previously published data of 301 controls and 325 patients were also considered (<i>P</i> ≤ 0.0002). In addition, we found that the proportion of male patients with homozygous minor alleles at <i>rs2114724</i> was significantly higher than that of females (<i>P</i> = 0.002Genetics research6698979https://www.ebi.ac.uk/biostudies/studies/S-EPMC8032507biostudies-literatureFunctional Analysis of <i>DNMT1</i> SNPs (<i>rs2228611</i> and <i>rs2114724</i>) Associated with Schizophrenia.PMC8032507Prasad Rao GSaxena SNaik PChennoju KVoina VCRamasubramanian CGowdhaman KChoudhury SNarayan KPMaroju PAKkani PJamma TGanesh Kumar SMohan KNfalseFunctional Analysis of <i>DNMT1</i> SNPs (<i>rs2228611</i> and <i>rs2114724</i>) Associated with Schizophrenia.A recent study showed the association of minor alleles of <i>rs2228611</i> (T allele) and <i>rs2114724</i> (T allele) of <i>DNMT1</i> with schizophrenia (SZ) and suggested their effects on splicing of the transcripts. We performed a replication study using 310 controls and 304 SZ patients and confirmed the association of the homozygous minor allele genotypes with SZ (<i>P</i> = 0.04 for <i>rs2114724</i> and <i>P</i> = 0.007 for rs<i>2228611</i>). This significant association persisted after Bonferroni correction when the previously published data of 301 controls and 325 patients were also considered (<i>P</i> ≤ 0.0002). In addition, we found that the proportion of male patients with homozygous minor alleles at <i>rs2114724</i> was significantly higher than that of females (<i>P</i> = 0.0022021-01-01T00:00:00Z20212026-05-08T09:19:14.682Z2022-02-09T16:02:32.226ZS-EPMC80325073385440710.1155/2021/6698979