{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(5)"],"submitter":["Yang L"],"pubmed_abstract":["<h4>Background</h4>Ventricular-like human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) exhibit the electrophysiological characteristics of spontaneous beating. Previous studies demonstrated that dexmedetomidine (DMED), a highly selective and widely used α<sub>2</sub>-adrenoceptor agonist for sedation, analgesia, and stress management, may induce antiarrhythmic effects, especially ventricular tachycardia. However, the underlying mechanisms of the DMED-mediated antiarrhythmic effects remain to be fully elucidated.<h4>Methods</h4>A conventional patch-clamp recording method was used to investigate the direct effects of DMED on spontaneous action potentials, pacemaker currents (<i>I</i> <sub>f</sub>), potassium (K<sup>+</sup>) channel currents (<i>I</i> <sub>K1</sub> and <i>"],"journal":["Annals of translational medicine"],"pagination":["399"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8033317"],"repository":["biostudies-literature"],"pubmed_title":["Dexmedetomidine exhibits antiarrhythmic effects on human-induced pluripotent stem cell-derived cardiomyocytes through a Na/Ca channel-mediated mechanism."],"pmcid":["PMC8033317"],"pubmed_authors":["Zheng J","Witman N","Wu L","Yang L","Zhang J","Tan Y","Fu W","Wang W","Gong Y"],"additional_accession":[]},"is_claimable":false,"name":"Dexmedetomidine exhibits antiarrhythmic effects on human-induced pluripotent stem cell-derived cardiomyocytes through a Na/Ca channel-mediated mechanism.","description":"<h4>Background</h4>Ventricular-like human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) exhibit the electrophysiological characteristics of spontaneous beating. Previous studies demonstrated that dexmedetomidine (DMED), a highly selective and widely used α<sub>2</sub>-adrenoceptor agonist for sedation, analgesia, and stress management, may induce antiarrhythmic effects, especially ventricular tachycardia. However, the underlying mechanisms of the DMED-mediated antiarrhythmic effects remain to be fully elucidated.<h4>Methods</h4>A conventional patch-clamp recording method was used to investigate the direct effects of DMED on spontaneous action potentials, pacemaker currents (<i>I</i> <sub>f</sub>), potassium (K<sup>+</sup>) channel currents (<i>I</i> <sub>K1</sub> and <i>","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-04T21:24:34.013Z","creation":"2025-04-04T21:24:34.013Z"},"accession":"S-EPMC8033317","cross_references":{"pubmed":["33842620"],"doi":["10.21037/atm-20-5898"]}}