biostudies-literatureUnknown9(5)Mao Y<h4>Background</h4>Subxiphoid approach for mediastinal tumor resection was reported to provide a better view and less postoperative pain. Non-intubated video-assisted thoracic surgery (NI-VATS) without muscle relaxant would decrease the possibility of postoperative airway collapse for anterior mediastinal mass operation. Herein, we sought to describe the use of NI-VATS through subxiphoid approach for anterior mediastinal tumor resection.<h4>Methods</h4>In this retrospective cohort study, patients that underwent subxiphoid VATS resection for anterior mediastinal tumor between December 2015 and September 2019 were divided into two groups: NI-VATS and intubated VATS (I-VATS). Intraoperative and postoperative variables were compared.<h4>Results</h4>A total of 40 patients were included. Among them, 21 patients received NI-VATS (52.5%) and 19 were treated with I-VATS (47.5%). In total, intraoperative (4/21 <i>vs</i>. 2/19; P=0.446) and postoperative complications (5/21 <i>vs</i>. 7/19; P=0.369) were similar between NI-VATS and I-VATS group. The anesthesia time (231.76 <i>vs</i>. 244.71 min; P=0.218), the operation time (152.35 <i>vs</i>. 143.64 min; P=0.980), chest tube duration (1.81 <i>vs</i>. 1.84 days; P=0.08), the total volume (351.95 <i>vs</i>. 348.00 mL; P=0.223), post-operative pain scores (2.79 <i>vs</i>. 2.93, P=0.413), and the length of stay (9.47 <i>vs</i>. 10.57 days; P=0.970) were all comparable between two groups.<h4>Conclusions</h4>NI-VATS for mediastinal tumor resection via subxiphoid approach is a safe and technically feasible option in selected patients, which leads to comparable perioperative clinical outcomes when compared with I-VATS via the subxiphoid approach. This technique could be used as an alteration when intubation is not available.Annals of translational medicine403https://www.ebi.ac.uk/biostudies/studies/S-EPMC8033331biostudies-literatureNon-intubated video-assisted thoracic surgery for subxiphoid anterior mediastinal tumor resection.PMC8033331Qiu YDeng SJiang LLiang HHe JChen HZhou YMao YfalseNon-intubated video-assisted thoracic surgery for subxiphoid anterior mediastinal tumor resection.<h4>Background</h4>Subxiphoid approach for mediastinal tumor resection was reported to provide a better view and less postoperative pain. Non-intubated video-assisted thoracic surgery (NI-VATS) without muscle relaxant would decrease the possibility of postoperative airway collapse for anterior mediastinal mass operation. Herein, we sought to describe the use of NI-VATS through subxiphoid approach for anterior mediastinal tumor resection.<h4>Methods</h4>In this retrospective cohort study, patients that underwent subxiphoid VATS resection for anterior mediastinal tumor between December 2015 and September 2019 were divided into two groups: NI-VATS and intubated VATS (I-VATS). Intraoperative and postoperative variables were compared.<h4>Results</h4>A total of 40 patients were included. Among them, 21 patients received NI-VATS (52.5%) and 19 were treated with I-VATS (47.5%). In total, intraoperative (4/21 <i>vs</i>. 2/19; P=0.446) and postoperative complications (5/21 <i>vs</i>. 7/19; P=0.369) were similar between NI-VATS and I-VATS group. The anesthesia time (231.76 <i>vs</i>. 244.71 min; P=0.218), the operation time (152.35 <i>vs</i>. 143.64 min; P=0.980), chest tube duration (1.81 <i>vs</i>. 1.84 days; P=0.08), the total volume (351.95 <i>vs</i>. 348.00 mL; P=0.223), post-operative pain scores (2.79 <i>vs</i>. 2.93, P=0.413), and the length of stay (9.47 <i>vs</i>. 10.57 days; P=0.970) were all comparable between two groups.<h4>Conclusions</h4>NI-VATS for mediastinal tumor resection via subxiphoid approach is a safe and technically feasible option in selected patients, which leads to comparable perioperative clinical outcomes when compared with I-VATS via the subxiphoid approach. This technique could be used as an alteration when intubation is not available.2021-01-01T00:00:00Z2021 Mar2025-04-04T21:25:00.796Z2025-04-04T21:25:00.796ZS-EPMC80333313384262410.21037/atm-20-6125