biostudies-literatureWang MNatural Science Foundation of Hunan Province of ChinaNational Natural Science Foundation of China3327-3338https://www.ebi.ac.uk/biostudies/studies/S-EPMC8034472biostudies-literatureUnknown25(7)<h4>Background</h4>MicroRNAs (miRNAs) are widely distributed in cells and participate in the regulation of the pathophysiological process of many diseases. As an important part of non-coding RNA, miRNAs regulate a variety of molecules and signal pathways in tumour cells. However, the evidence for regulatory mechanisms of specific miRNAs in tumour cells is still lacking.<h4>Methods</h4>In this study, we used transcriptomics analysis and integrated a variety of public databases to screen miRNAs that have key regulatory effects on breast cancer (BC). In addition, we used in vitro and in vivo studies and combined clinical samples to verify its regulatory mechanism.<h4>Results</h4>We found that among the specific miRNAs, miR-215-5p is a key regulator in BC. Compared with normal adjacent tissuesJournal of cellular and molecular medicineIntegrated study of miR-215 promoting breast cancer cell apoptosis by targeting RAD54B.PMC80344728147040812JJ4084Wang MLiao JLi YTan CWu WZhou HWang JWang KfalseIntegrated study of miR-215 promoting breast cancer cell apoptosis by targeting RAD54B.<h4>Background</h4>MicroRNAs (miRNAs) are widely distributed in cells and participate in the regulation of the pathophysiological process of many diseases. As an important part of non-coding RNA, miRNAs regulate a variety of molecules and signal pathways in tumour cells. However, the evidence for regulatory mechanisms of specific miRNAs in tumour cells is still lacking.<h4>Methods</h4>In this study, we used transcriptomics analysis and integrated a variety of public databases to screen miRNAs that have key regulatory effects on breast cancer (BC). In addition, we used in vitro and in vivo studies and combined clinical samples to verify its regulatory mechanism.<h4>Results</h4>We found that among the specific miRNAs, miR-215-5p is a key regulator in BC. Compared with normal adjacent tissues2021-01-01T00:00:00Z2021 Apr2025-05-18T11:17:18.844Z2025-05-18T11:17:18.844ZS-EPMC80344723363559110.1111/jcmm.16402