{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bareja A"],"funding":["NIA NIH HHS","NHLBI NIH HHS","NIH"],"pagination":["111443"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8035222"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["195"],"pubmed_abstract":["Caloric restriction (CR) can prolong aged skeletal muscle function, yet the molecular mechanisms are not completely understood. We performed phosphoproteomic analysis on muscle from young and old mice fed an ad libitum diet, and old mice fed a CR diet. CR promoted a youthful phosphoproteomic signature, suppressing several known \"pro-aging\" pathways including Protein kinase A (PKA). This study validates global signaling changes in skeletal muscle during CR."],"journal":["Mechanisms of ageing and development"],"pubmed_title":["Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle."],"pmcid":["PMC8035222"],"funding_grant_id":["K01 AG056664","T32 HL007057","P30 AG028716"],"pubmed_authors":["White JP","Grimsrud PA","Katz LH","Lee DE","Bareja A","Draper JA"],"additional_accession":[]},"is_claimable":false,"name":"Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle.","description":"Caloric restriction (CR) can prolong aged skeletal muscle function, yet the molecular mechanisms are not completely understood. We performed phosphoproteomic analysis on muscle from young and old mice fed an ad libitum diet, and old mice fed a CR diet. CR promoted a youthful phosphoproteomic signature, suppressing several known \"pro-aging\" pathways including Protein kinase A (PKA). This study validates global signaling changes in skeletal muscle during CR.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-29T11:33:45.293Z","creation":"2025-04-06T19:54:44.794Z"},"accession":"S-EPMC8035222","cross_references":{"pubmed":["33529682"],"doi":["10.1016/j.mad.2021.111443"]}}