{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alsaggaf R"],"funding":["Intramural NIH HHS","NCI NIH HHS","National Institutes of Health","Office of Academic Research, U.S. Naval Academy"],"pagination":["313.e1-313.e8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8036238"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(4)"],"pubmed_abstract":["Cellular aging in hematopoietic cell transplantation (HCT) is important in the context of immune reconstitution and age-related complications. Recently, several DNA-methylation (DNAm)-based biomarkers of aging known as \"epigenetic clocks\" have been introduced as novel tools to predict cellular age. Here, we used Cox proportional hazards models to assess the possible associations of donor pre-HCT DNAm age, and its post-HCT changes, using the recently published lifespan-associated epigenetic clock known as \"DNAm-GrimAge,\" with outcomes among patients with severe aplastic anemia (SAA). The study included 732 SAA patients from the Transplant Outcomes in Aplastic Anemia project, who underwent unrelated donor HCT and for whom a donor pre-HCT blood DNA sample was available; 41 also had a post-HCT"],"journal":["Transplantation and cellular therapy"],"pubmed_title":["Epigenetic Aging and Hematopoietic Cell Transplantation in Patients With Severe Aplastic Anemia."],"pmcid":["PMC8036238"],"funding_grant_id":["U24 CA076518","Z99 CA999999"],"pubmed_authors":["Hicks BD","Alsaggaf R","Lee SJ","Wang T","Gadalla SM","Katta S","Zhu B","Horvath S","Spellman SR"],"additional_accession":[]},"is_claimable":false,"name":"Epigenetic Aging and Hematopoietic Cell Transplantation in Patients With Severe Aplastic Anemia.","description":"Cellular aging in hematopoietic cell transplantation (HCT) is important in the context of immune reconstitution and age-related complications. Recently, several DNA-methylation (DNAm)-based biomarkers of aging known as \"epigenetic clocks\" have been introduced as novel tools to predict cellular age. Here, we used Cox proportional hazards models to assess the possible associations of donor pre-HCT DNAm age, and its post-HCT changes, using the recently published lifespan-associated epigenetic clock known as \"DNAm-GrimAge,\" with outcomes among patients with severe aplastic anemia (SAA). The study included 732 SAA patients from the Transplant Outcomes in Aplastic Anemia project, who underwent unrelated donor HCT and for whom a donor pre-HCT blood DNA sample was available; 41 also had a post-HCT","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-29T11:33:38.705Z","creation":"2025-04-06T19:54:36.964Z"},"accession":"S-EPMC8036238","cross_references":{"pubmed":["33836872"],"doi":["10.1016/j.jtct.2021.01.013"]}}