biostudies-literatureMilstone AMAHRQ HHS431-439https://www.ebi.ac.uk/biostudies/studies/S-EPMC8039053biostudies-literatureUnknown42(4)<h4>Objective</h4>To evaluate the effect of 70% isopropyl alcohol-impregnated central venous catheter caps on ambulatory central-line-associated bloodstream infections (CLABSIs) in pediatric hematology-oncology patients.<h4>Design</h4>This study was a 24-month, cluster-randomized, 2 period, crossover clinical trial.<h4>Setting</h4>The study was conducted in 15 pediatric healthcare institutions, including 16 pediatric hematology-oncology clinics.<h4>Participants</h4>All patients with an external central line followed at 1 of the 16 hematology-oncology clinics.<h4>Intervention</h4>Usual ambulatory central-line care per each institution using 70% isopropyl alcohol-impregnated caps at home compared to usual ambulatory central-line care in each institution without using 70% isopropyl alcohol-imInfection control and hospital epidemiologyAlcohol-impregnated caps and ambulatory central-line-associated bloodstream infections (CLABSIs): A randomized clinical trial.PMC8039053R01 HS022870Rosenberg CYenokyan GKoontz DWMiller MRCCLIP Authorship GroupMilstone AMfalseAlcohol-impregnated caps and ambulatory central-line-associated bloodstream infections (CLABSIs): A randomized clinical trial.<h4>Objective</h4>To evaluate the effect of 70% isopropyl alcohol-impregnated central venous catheter caps on ambulatory central-line-associated bloodstream infections (CLABSIs) in pediatric hematology-oncology patients.<h4>Design</h4>This study was a 24-month, cluster-randomized, 2 period, crossover clinical trial.<h4>Setting</h4>The study was conducted in 15 pediatric healthcare institutions, including 16 pediatric hematology-oncology clinics.<h4>Participants</h4>All patients with an external central line followed at 1 of the 16 hematology-oncology clinics.<h4>Intervention</h4>Usual ambulatory central-line care per each institution using 70% isopropyl alcohol-impregnated caps at home compared to usual ambulatory central-line care in each institution without using 70% isopropyl alcohol-im2021-01-01T00:00:00Z2021 Apr2026-05-02T22:39:43.386Z2025-04-07T07:25:35.093ZS-EPMC80390533304075510.1017/ice.2020.467