{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(3)"],"submitter":["Stormont GD"],"pubmed_abstract":["Infertility affects approximately 15% of couples. With infertility such a common problem in a generally healthy age group, complete evaluation is needed of both men and women. Infertility work up for men includes a semen analysis, the results of which suggest various supplemental studies, including karyotype. Karyotype is indicated when a patient has findings on history or physical exam concerning for chromosomal abnormalities, azoospermia, or severe oligospermia (count <5 million/mL). The most common chromosomal numerical abnormality found on karyotype is Klinefelter syndrome which is classified as redundant sex chromosomes, with the most common chromosomal arrangement being 47, XXY. If a patient is found to have a chromosomal abnormality such as Klinefelter's, there is still a chance of fertility using testicular sperm extraction and in-vitro fertilization."],"journal":["Translational andrology and urology"],"pagination":["1365-1372"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8039619"],"repository":["biostudies-literature"],"pubmed_title":["Genetic causes and management of male infertility."],"pmcid":["PMC8039619"],"pubmed_authors":["Stormont GD","Deibert CM"],"additional_accession":[]},"is_claimable":false,"name":"Genetic causes and management of male infertility.","description":"Infertility affects approximately 15% of couples. With infertility such a common problem in a generally healthy age group, complete evaluation is needed of both men and women. Infertility work up for men includes a semen analysis, the results of which suggest various supplemental studies, including karyotype. Karyotype is indicated when a patient has findings on history or physical exam concerning for chromosomal abnormalities, azoospermia, or severe oligospermia (count <5 million/mL). The most common chromosomal numerical abnormality found on karyotype is Klinefelter syndrome which is classified as redundant sex chromosomes, with the most common chromosomal arrangement being 47, XXY. If a patient is found to have a chromosomal abnormality such as Klinefelter's, there is still a chance of fertility using testicular sperm extraction and in-vitro fertilization.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-27T00:10:30.042Z","creation":"2025-04-06T17:46:57.168Z"},"accession":"S-EPMC8039619","cross_references":{"pubmed":["33850772"],"doi":["10.21037/tau.2020.03.34"]}}