biostudies-literatureUnknown9(6)Yi C<h4>Background</h4>Currently, the tumor, node, and metastasis (TNM) staging system has a limited value in prognostic stratification for neuroendocrine tumors of the lung (NETL). A specific pathological staging system was therefore explored.<h4>Methods</h4>Two cohorts were assessed: the training cohort was composed of surgically treated patients from the Surveillance, Epidemiologic, and End Results (SEER) database [2004-2015]; the Shanghai cohort included Shanghai resident patients treated at Shanghai Pulmonary Hospital [2009-2018]. Multivariable Cox regression analysis was performed to identify factors associated with overall survival. A new staging system was proposed based on survival tree, and was further compared with the 8^th edition of the TNM staging system.<h4>Results</h4Annals of translational medicine447https://www.ebi.ac.uk/biostudies/studies/S-EPMC8039668biostudies-literatureImprovement of pathological staging system for neuroendocrine tumors of the lung.PMC8039668Song NZhu YJiang GZhang HWu CYi CZhang LDai JZhang PfalseImprovement of pathological staging system for neuroendocrine tumors of the lung.<h4>Background</h4>Currently, the tumor, node, and metastasis (TNM) staging system has a limited value in prognostic stratification for neuroendocrine tumors of the lung (NETL). A specific pathological staging system was therefore explored.<h4>Methods</h4>Two cohorts were assessed: the training cohort was composed of surgically treated patients from the Surveillance, Epidemiologic, and End Results (SEER) database [2004-2015]; the Shanghai cohort included Shanghai resident patients treated at Shanghai Pulmonary Hospital [2009-2018]. Multivariable Cox regression analysis was performed to identify factors associated with overall survival. A new staging system was proposed based on survival tree, and was further compared with the 8^th edition of the TNM staging system.<h4>Results</h42021-01-01T00:00:00Z2021 Mar2025-04-04T21:24:34.784Z2025-04-04T21:24:34.784ZS-EPMC80396683385084410.21037/atm-20-5910