{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lopez Angel CJ"],"funding":["HHS | National Institutes of Health"],"pagination":["e2022928118"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8040665"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["118(14)"],"pubmed_abstract":["Chronic inflammation is thought to be a major cause of morbidity and mortality in aging, but whether similar mechanisms underlie dysfunction in infection-associated chronic inflammation is unclear. Here, we profiled the immune proteome, and cellular composition and signaling states in a cohort of aging individuals versus a set of HIV patients on long-term antiretroviral therapy therapy or hepatitis C virus (HCV) patients before and after sofosbuvir treatment. We found shared alterations in aging-associated and infection-associated chronic inflammation including T cell memory inflation, up-regulation of intracellular signaling pathways of inflammation, and diminished sensitivity to cytokines in lymphocytes and myeloid cells. In the HIV cohort, these dysregulations were evident despite viral"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Signatures of immune dysfunction in HIV and HCV infection share features with chronic inflammation in aging and persist after viral reduction or elimination."],"pmcid":["PMC8040665"],"funding_grant_id":["U19 AI057229"],"pubmed_authors":["Rosenberg-Hasson Y","Lopez Angel CJ","Dekker CL","Grant PM","Nguyen T","Glenn JS","Vallania F","Khatri P","Pham EA","Fram BJ","Maecker HT","Du H","Davis MM","Ahmed A","Furman D","Perez K"],"additional_accession":[]},"is_claimable":false,"name":"Signatures of immune dysfunction in HIV and HCV infection share features with chronic inflammation in aging and persist after viral reduction or elimination.","description":"Chronic inflammation is thought to be a major cause of morbidity and mortality in aging, but whether similar mechanisms underlie dysfunction in infection-associated chronic inflammation is unclear. Here, we profiled the immune proteome, and cellular composition and signaling states in a cohort of aging individuals versus a set of HIV patients on long-term antiretroviral therapy therapy or hepatitis C virus (HCV) patients before and after sofosbuvir treatment. We found shared alterations in aging-associated and infection-associated chronic inflammation including T cell memory inflation, up-regulation of intracellular signaling pathways of inflammation, and diminished sensitivity to cytokines in lymphocytes and myeloid cells. In the HIV cohort, these dysregulations were evident despite viral","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-26T08:17:16.367Z","creation":"2022-02-09T15:32:53.425Z"},"accession":"S-EPMC8040665","cross_references":{"pubmed":["33811141"],"doi":["10.1073/pnas.2022928118"]}}