biostudies-literatureMartinisi ASwiss National Science Foundationthe Synapsis Foundation Switzerland963-974https://www.ebi.ac.uk/biostudies/studies/S-EPMC8041046biostudies-literatureUnknown144(3)Tau is a microtubule stabilizing protein that forms abnormal aggregates in many neurodegenerative disorders, including Alzheimer's disease. We have previously shown that co-expression of fragmented and full-length tau in P301SxTAU62on tau transgenic mice results in the formation of oligomeric tau species and causes severe paralysis. This paralysis is fully reversible once expression of the tau fragment is halted, even though P301S tau expression is maintained. Whereas various strategies to target tau aggregation have been developed, little is known about the long-term consequences of reverted tau toxicity. Therefore, we studied the long-term motor fitness of recovered, formerly paralysed P301SxTAU62on-off mice. To assess the seeding competence of oligomeric toxic tau species, we also inocuBrain : a journal of neurologySevere oligomeric tau toxicity can be reversed without long-term sequelae.PMC804104615284632323B_123812310030_16948631003A_152846Frank SWinkler DTMartinisi ASprenger FFlach MTolnay MfalseSevere oligomeric tau toxicity can be reversed without long-term sequelae.Tau is a microtubule stabilizing protein that forms abnormal aggregates in many neurodegenerative disorders, including Alzheimer's disease. We have previously shown that co-expression of fragmented and full-length tau in P301SxTAU62on tau transgenic mice results in the formation of oligomeric tau species and causes severe paralysis. This paralysis is fully reversible once expression of the tau fragment is halted, even though P301S tau expression is maintained. Whereas various strategies to target tau aggregation have been developed, little is known about the long-term consequences of reverted tau toxicity. Therefore, we studied the long-term motor fitness of recovered, formerly paralysed P301SxTAU62on-off mice. To assess the seeding competence of oligomeric toxic tau species, we also inocu2021-01-01T00:00:00Z2021 Apr2025-04-04T18:37:50.139Z2022-02-09T15:38:46.501ZS-EPMC80410463348411610.1093/brain/awaa445