biostudies-literatureUnknown34(2)Grazzini IIdiopathic normal pressure hydrocephalus (iNPH) is a syndrome that comprises a triad of gait disturbance, dementia and urinary incontinence, associated with ventriculomegaly in the absence of elevated intraventricular cerebrospinal fluid (CSF) pressure. It is important to identify patients with iNPH because some of its clinical features may be reversed by the insertion of a CSF shunt. The diagnosis is based on clinical history, physical examination and brain imaging, especially magnetic resonance imaging (MRI). Recently, some papers have investigated the role of diffusion tensor imaging (DTI) in evaluating white matter alterations in patients with iNPH. DTI analysis in specific anatomical regions seems to be a promising MR biomarker of iNPH and could also be used in the differential diagnoThe neuroradiology journal55-69https://www.ebi.ac.uk/biostudies/studies/S-EPMC8041402biostudies-literatureThe role of diffusion tensor imaging in idiopathic normal pressure hydrocephalus: A literature review.PMC8041402Cuneo GLVenezia DGrazzini IfalseThe role of diffusion tensor imaging in idiopathic normal pressure hydrocephalus: A literature review.Idiopathic normal pressure hydrocephalus (iNPH) is a syndrome that comprises a triad of gait disturbance, dementia and urinary incontinence, associated with ventriculomegaly in the absence of elevated intraventricular cerebrospinal fluid (CSF) pressure. It is important to identify patients with iNPH because some of its clinical features may be reversed by the insertion of a CSF shunt. The diagnosis is based on clinical history, physical examination and brain imaging, especially magnetic resonance imaging (MRI). Recently, some papers have investigated the role of diffusion tensor imaging (DTI) in evaluating white matter alterations in patients with iNPH. DTI analysis in specific anatomical regions seems to be a promising MR biomarker of iNPH and could also be used in the differential diagno2021-01-01T00:00:00Z2021 Apr2026-06-03T18:35:38.453Z2025-04-06T19:54:32.63ZS-EPMC80414023326349410.1177/1971400920975153