{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Maruyama K"],"funding":["Core Research for Evolutional Science and Technology","Ministry of Education, Culture, Sports, Science and Technology","Japan Science and Technology Agency"],"pagination":["102305"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8041864"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(4)"],"pubmed_abstract":["Blood and lymphatic vessels surrounding the heart develop through orchestrated processes from cells of different origins. In particular, cells around the outflow tract which constitute a primordial transient vasculature, referred to as aortic subepicardial vessels, are crucial for the establishment of coronary artery stems and cardiac lymphatic vessels. Here, we revealed that the epicardium and pericardium-derived Semaphorin 3E (Sema3E) and its receptor, PlexinD1, play a role in the development of the coronary stem, as well as cardiac lymphatic vessels. <i>In vitro</i> analyses demonstrated that Sema3E may demarcate areas to repel PlexinD1-expressing lymphatic endothelial cells, resulting in proper coronary and lymphatic vessel formation. Furthermore, inactivation of Sema3E-PlexinD1 signaling improved the recovery of cardiac function by increasing reactive lymphangiogenesis in an adult mouse model of myocardial infarction. These findings may lead to therapeutic strategies that target Sema3E-PlexinD1 signaling in coronary artery diseases."],"journal":["iScience"],"pubmed_title":["Semaphorin3E-PlexinD1 signaling in coronary artery and lymphatic vessel development with clinical implications in myocardial recovery."],"pmcid":["PMC8041864"],"funding_grant_id":["20K17072","19H01048","JPMJCR13W2"],"pubmed_authors":["Kurihara Y","Uchijima Y","Singh MK","Miyagawa-Tomita S","Nagao H","Kurihara H","Naemura K","Yoshihara K","Matsuzaki F","Maruyama K","Uemura A","Yoshida Y","Arima Y"],"additional_accession":[]},"is_claimable":false,"name":"Semaphorin3E-PlexinD1 signaling in coronary artery and lymphatic vessel development with clinical implications in myocardial recovery.","description":"Blood and lymphatic vessels surrounding the heart develop through orchestrated processes from cells of different origins. In particular, cells around the outflow tract which constitute a primordial transient vasculature, referred to as aortic subepicardial vessels, are crucial for the establishment of coronary artery stems and cardiac lymphatic vessels. Here, we revealed that the epicardium and pericardium-derived Semaphorin 3E (Sema3E) and its receptor, PlexinD1, play a role in the development of the coronary stem, as well as cardiac lymphatic vessels. <i>In vitro</i> analyses demonstrated that Sema3E may demarcate areas to repel PlexinD1-expressing lymphatic endothelial cells, resulting in proper coronary and lymphatic vessel formation. Furthermore, inactivation of Sema3E-PlexinD1 signaling improved the recovery of cardiac function by increasing reactive lymphangiogenesis in an adult mouse model of myocardial infarction. These findings may lead to therapeutic strategies that target Sema3E-PlexinD1 signaling in coronary artery diseases.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2026-05-08T00:35:42.273Z","creation":"2026-05-01T03:04:53.984Z"},"accession":"S-EPMC8041864","cross_references":{"pubmed":["33870127"],"doi":["10.1016/j.isci.2021.102305"]}}