biostudies-literatureWang AChina Scholarship CouncilNational Key R&D Program of ChinaNational Natural Science Foundation of China1-15https://www.ebi.ac.uk/biostudies/studies/S-EPMC8043178biostudies-literatureUnknown13(1)The capability of carbohydrate utilization in fish is limited compared to mammals. It has scientific and practical significance to improve the ability of fish to use carbohydrates. The efficiency of dietary carbohydrate utilization varies among fish with different feeding habits, which are associated with differential intestinal microbiota. In this study, we found that zebrafish fed with omnivorous diet (OD) and herbivorous diet (HD) showed better glucose homeostasis compared with carnivorous diet (CD) fed counterpart and the differential glucose utilization efficiency was attributable to the intestinal microbiota. The commensal bacterium <i>Cetobacterium somerae</i>, an acetate producer, was enriched in OD and HD groups, and administration of <i>C. somerae</i> in both adult zebrafish and Gut microbesIntestinal <i>Cetobacterium</i> and acetate modify glucose homeostasis via parasympathetic activation in zebrafish.PMC80431783180231531872584319728072018YFD090040031925038Yang YRan CWang AZhang ZBindelle JDing QZhou ZfalseIntestinal <i>Cetobacterium</i> and acetate modify glucose homeostasis via parasympathetic activation in zebrafish.The capability of carbohydrate utilization in fish is limited compared to mammals. It has scientific and practical significance to improve the ability of fish to use carbohydrates. The efficiency of dietary carbohydrate utilization varies among fish with different feeding habits, which are associated with differential intestinal microbiota. In this study, we found that zebrafish fed with omnivorous diet (OD) and herbivorous diet (HD) showed better glucose homeostasis compared with carnivorous diet (CD) fed counterpart and the differential glucose utilization efficiency was attributable to the intestinal microbiota. The commensal bacterium <i>Cetobacterium somerae</i>, an acetate producer, was enriched in OD and HD groups, and administration of <i>C. somerae</i> in both adult zebrafish and 2021-01-01T00:00:00Z2021 Jan-Dec2026-05-09T07:49:55.19Z2022-02-10T20:25:08.396ZS-EPMC80431783384037110.1080/19490976.2021.1900996