biostudies-literatureUnknown49(4)Pilgram LUniversitätsklinikum Essen<h4>Purpose</h4>The ongoing pandemic caused by the novel severe acute respiratory coronavirus 2 (SARS-CoV-2) has stressed health systems worldwide. Patients with chronic kidney disease (CKD) seem to be more prone to a severe course of coronavirus disease (COVID-19) due to comorbidities and an altered immune system. The study's aim was to identify factors predicting mortality among SARS-CoV-2-infected patients with CKD.<h4>Methods</h4>We analyzed 2817 SARS-CoV-2-infected patients enrolled in the Lean European Open Survey on SARS-CoV-2-infected patients and identified 426 patients with pre-existing CKD. Group comparisons were performed via Chi-squared test. Using univariate and multivariable logistic regression, predictive factors for mortality were identified.<h4>Results</h4>Comparative anaInfection725-737https://www.ebi.ac.uk/biostudies/studies/S-EPMC8043429biostudies-literatureClinical course and predictive risk factors for fatal outcome of SARS-CoV-2 infection in patients with chronic kidney disease.PMC8043429Rauschning DMueller-Joerger GFuerst JNattermann JClassen ARueddel JPeetz HWille KBethge WGruener BPrasser FKoehler FCSchubert JVehreschild JJStieglitz SEberwein LKeller UDolff SWalter LHower Mvon Bergwelt-Baildon MRitter ASchulze NTometten LHohenstein BHanses FMerle UVehreschild MRuthrich MRaichle CRuethrich MHellwig KRieg SBurst VSpinner CHeigener DFriedrichs AFranke BBeutel GLablans MLanznaster JWettstein MDroehmann DKielstein JTIsberner NGuggemos WRothfuss KNeufang Mde With KPilgram LMuller RUJakob CEMBorgmann SStecher MDegenhardt CTrauth JWorm MFuhrmann SWeidemann ABrandenburger TBals RPiepel CJung NLEOSS Study groupSchons MSchultheis BPrattes JfalseClinical course and predictive risk factors for fatal outcome of SARS-CoV-2 infection in patients with chronic kidney disease.<h4>Purpose</h4>The ongoing pandemic caused by the novel severe acute respiratory coronavirus 2 (SARS-CoV-2) has stressed health systems worldwide. Patients with chronic kidney disease (CKD) seem to be more prone to a severe course of coronavirus disease (COVID-19) due to comorbidities and an altered immune system. The study's aim was to identify factors predicting mortality among SARS-CoV-2-infected patients with CKD.<h4>Methods</h4>We analyzed 2817 SARS-CoV-2-infected patients enrolled in the Lean European Open Survey on SARS-CoV-2-infected patients and identified 426 patients with pre-existing CKD. Group comparisons were performed via Chi-squared test. Using univariate and multivariable logistic regression, predictive factors for mortality were identified.<h4>Results</h4>Comparative ana2021-01-01T00:00:00Z2021 Aug2025-04-26T10:59:27.727Z2022-02-11T06:25:49.192ZS-EPMC80434293385132810.1007/s15010-021-01597-7