biostudies-literatureHebscher MNIMH NIH HHSNational Institute of Mental Health1428-1437.e5https://www.ebi.ac.uk/biostudies/studies/S-EPMC8044012biostudies-literatureUnknown31(7)Episodic memory involves the reinstatement of distributed patterns of brain activity present when events were initially experienced. The hippocampus is thought to coordinate reinstatement via its interactions with a network of brain regions, but this hypothesis has not been causally tested in humans. The current study directly tested the involvement of the hippocampal network in reinstatement using network-targeted noninvasive stimulation. We measured reinstatement of multi-voxel patterns of functional magnetic resonance imaging (fMRI) activity during encoding and retrieval of naturalistic video clips depicting everyday activities. Reinstatement of video-specific activity patterns was robust in posterior parietal and occipital areas previously implicated in event reinstatement. Theta-burstCurrent biology : CBEnhanced reinstatement of naturalistic event memories due to hippocampal-network-targeted stimulation.PMC8044012R01 MH106512Voss JLKragel JEKahnt THebscher MfalseEnhanced reinstatement of naturalistic event memories due to hippocampal-network-targeted stimulation.Episodic memory involves the reinstatement of distributed patterns of brain activity present when events were initially experienced. The hippocampus is thought to coordinate reinstatement via its interactions with a network of brain regions, but this hypothesis has not been causally tested in humans. The current study directly tested the involvement of the hippocampal network in reinstatement using network-targeted noninvasive stimulation. We measured reinstatement of multi-voxel patterns of functional magnetic resonance imaging (fMRI) activity during encoding and retrieval of naturalistic video clips depicting everyday activities. Reinstatement of video-specific activity patterns was robust in posterior parietal and occipital areas previously implicated in event reinstatement. Theta-burst2021-01-01T00:00:00Z2021 Apr2025-04-29T11:33:25.855Z2025-04-06T19:54:34.768ZS-EPMC80440123354504410.1016/j.cub.2021.01.027