{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Purcell JB"],"funding":["NCCDPHP CDC HHS","NIMH NIH HHS","NIAAA NIH HHS","National Institutes of Health"],"pagination":["108-123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8044018"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["137"],"pubmed_abstract":["<h4>Objective</h4>Childhood physical and sexual abuse are stressful experiences that may alter the emotional response to future stressors. Stress-related emotional function is supported by brain regions that include the prefrontal cortex (PFC), hippocampus, and amygdala. The present study investigated whether childhood physical and sexual abuse are associated with stress-elicited brain activity in young adulthood.<h4>Methods</h4>Participants (N = 300; M<sub>age</sub> = 20.0; 151 female) completed a psychosocial stress task during functional magnetic resonance imaging (fMRI). Measures of physical and sexual abuse were included in a linear mixed effects model to estimate the unique relationship each type of childhood abuse had with stress-elicited brain activity.<h4>Results</h4>Stress-elicited dorsolateral PFC, ventromedial PFC, and hippocampal activity decreased as the frequency of childhood sexual abuse increased. There were no regions in which stress-elicited activation varied with physical abuse.<h4>Conclusions</h4>The present findings suggest there is a unique relationship between childhood sexual abuse and the stress-elicited PFC and hippocampal activity of young adults that is not observed following childhood physical abuse.<h4>Significance</h4>These findings may have important implications for understanding the mechanisms by which childhood sexual abuse impacts the development of future psychopathology."],"journal":["Cortex; a journal devoted to the study of the nervous system and behavior"],"pubmed_title":["Stress-elicited neural activity in young adults varies with childhood sexual abuse."],"pmcid":["PMC8044018"],"funding_grant_id":["U48 DP000056","U19 DP002664","U19 DP002663","U48 DP000046","U48 DP000057","U19 DP002665","R01 MH098348","F31 AA027137"],"pubmed_authors":["Emery ST","Harnett NG","Mrug S","Goodman AM","Purcell JB","Schuster MA","Knight DC","Davis ES","Wheelock MD","Elliott MN"],"additional_accession":[]},"is_claimable":false,"name":"Stress-elicited neural activity in young adults varies with childhood sexual abuse.","description":"<h4>Objective</h4>Childhood physical and sexual abuse are stressful experiences that may alter the emotional response to future stressors. Stress-related emotional function is supported by brain regions that include the prefrontal cortex (PFC), hippocampus, and amygdala. The present study investigated whether childhood physical and sexual abuse are associated with stress-elicited brain activity in young adulthood.<h4>Methods</h4>Participants (N = 300; M<sub>age</sub> = 20.0; 151 female) completed a psychosocial stress task during functional magnetic resonance imaging (fMRI). Measures of physical and sexual abuse were included in a linear mixed effects model to estimate the unique relationship each type of childhood abuse had with stress-elicited brain activity.<h4>Results</h4>Stress-elicited dorsolateral PFC, ventromedial PFC, and hippocampal activity decreased as the frequency of childhood sexual abuse increased. There were no regions in which stress-elicited activation varied with physical abuse.<h4>Conclusions</h4>The present findings suggest there is a unique relationship between childhood sexual abuse and the stress-elicited PFC and hippocampal activity of young adults that is not observed following childhood physical abuse.<h4>Significance</h4>These findings may have important implications for understanding the mechanisms by which childhood sexual abuse impacts the development of future psychopathology.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-29T11:28:42.68Z","creation":"2025-04-06T19:55:13.174Z"},"accession":"S-EPMC8044018","cross_references":{"pubmed":["33609897"],"doi":["10.1016/j.cortex.2020.12.020"]}}