{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huo S"],"funding":["Guangdong Provincial Science and Technology Project","the Specific Fund of State Key Laboratory of Dampness Syndrome of Chinese Medicine","National Natural Science Foundation of China","the Joint Innovation Project of  National Center for Protein Sciences (Beijing) and Guangdong Provincial Hospital of Chinese Medicine","the Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine","the  National Key Research and Development Program of China"],"pagination":["9500-9508"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8047722"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(14)"],"pubmed_abstract":["Hyperuricemia (HUA), a chronic disease caused by metabolic disorders of purine, is often accompanied by other diseases such as gout, type 2 diabetes mellitus (T2DM), and hyperlipidemia. However, little is known about the relationship between HUA and these diseases on the protein level. We performed label-free liquid chromatography MS/MS spectrometry analysis of urine samples from 26 HUA patients and 25 healthy controls, attempting to establish the possible protein links between HUA and these diseases by profiling urine proteome. A total of 2119 proteins were characterized in sample proteomes. Among them, 11 were found decreased and 2 were found increased in HUA samples. Plausible pathways found by enrichment analysis of these differentially expressed proteins (DEPs) include the processes f"],"journal":["ACS omega"],"pubmed_title":["Urinary Proteomic Characteristics of Hyperuricemia and Their Possible Links with the Occurrence of Its Concomitant Diseases."],"pmcid":["PMC8047722"],"funding_grant_id":["81774216","SZ2020ZZ04","2017YFC0908403","YN2016XP01","31971360","2018B030322012","2017KT1821","SZ2020ZZ05","82074376"],"pubmed_authors":["Yan M","Xu P","Li C","Xie Y","Wang H","Shao C","Bao K","Huo S","Song T","Tian R","Mao W","Chen X","Zhu W","Liu F"],"additional_accession":[]},"is_claimable":false,"name":"Urinary Proteomic Characteristics of Hyperuricemia and Their Possible Links with the Occurrence of Its Concomitant Diseases.","description":"Hyperuricemia (HUA), a chronic disease caused by metabolic disorders of purine, is often accompanied by other diseases such as gout, type 2 diabetes mellitus (T2DM), and hyperlipidemia. However, little is known about the relationship between HUA and these diseases on the protein level. We performed label-free liquid chromatography MS/MS spectrometry analysis of urine samples from 26 HUA patients and 25 healthy controls, attempting to establish the possible protein links between HUA and these diseases by profiling urine proteome. A total of 2119 proteins were characterized in sample proteomes. Among them, 11 were found decreased and 2 were found increased in HUA samples. Plausible pathways found by enrichment analysis of these differentially expressed proteins (DEPs) include the processes f","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2026-04-07T15:13:43.908Z","creation":"2022-02-09T16:06:05.327Z"},"accession":"S-EPMC8047722","cross_references":{"pubmed":["33869930"],"doi":["10.1021/acsomega.0c06229"]}}