biostudies-literatureHuo SGuangdong Provincial Science and Technology Projectthe Specific Fund of State Key Laboratory of Dampness Syndrome of Chinese MedicineNational Natural Science Foundation of Chinathe Joint Innovation Project of National Center for Protein Sciences (Beijing) and Guangdong Provincial Hospital of Chinese Medicinethe Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicinethe National Key Research and Development Program of China9500-9508https://www.ebi.ac.uk/biostudies/studies/S-EPMC8047722biostudies-literatureUnknown6(14)Hyperuricemia (HUA), a chronic disease caused by metabolic disorders of purine, is often accompanied by other diseases such as gout, type 2 diabetes mellitus (T2DM), and hyperlipidemia. However, little is known about the relationship between HUA and these diseases on the protein level. We performed label-free liquid chromatography MS/MS spectrometry analysis of urine samples from 26 HUA patients and 25 healthy controls, attempting to establish the possible protein links between HUA and these diseases by profiling urine proteome. A total of 2119 proteins were characterized in sample proteomes. Among them, 11 were found decreased and 2 were found increased in HUA samples. Plausible pathways found by enrichment analysis of these differentially expressed proteins (DEPs) include the processes fACS omegaUrinary Proteomic Characteristics of Hyperuricemia and Their Possible Links with the Occurrence of Its Concomitant Diseases.PMC804772281774216SZ2020ZZ042017YFC0908403YN2016XP01319713602018B0303220122017KT1821SZ2020ZZ0582074376Yan MXu PLi CXie YWang HShao CBao KHuo SSong TTian RMao WChen XZhu WLiu FfalseUrinary Proteomic Characteristics of Hyperuricemia and Their Possible Links with the Occurrence of Its Concomitant Diseases.Hyperuricemia (HUA), a chronic disease caused by metabolic disorders of purine, is often accompanied by other diseases such as gout, type 2 diabetes mellitus (T2DM), and hyperlipidemia. However, little is known about the relationship between HUA and these diseases on the protein level. We performed label-free liquid chromatography MS/MS spectrometry analysis of urine samples from 26 HUA patients and 25 healthy controls, attempting to establish the possible protein links between HUA and these diseases by profiling urine proteome. A total of 2119 proteins were characterized in sample proteomes. Among them, 11 were found decreased and 2 were found increased in HUA samples. Plausible pathways found by enrichment analysis of these differentially expressed proteins (DEPs) include the processes f2021-01-01T00:00:00Z2021 Apr2026-04-07T15:13:43.908Z2022-02-09T16:06:05.327ZS-EPMC80477223386993010.1021/acsomega.0c06229