biostudies-literatureElnabawi YANational Psoriasis FoundationAmerican Heart AssociationNCATS NIH HHSRheumatology Research FoundationNHLBI NIH HHSDermatology FoundationAmerican Society of HematologyNational Institutes of HealthNIAMS NIH HHS913-920https://www.ebi.ac.uk/biostudies/studies/S-EPMC8049184biostudies-literatureUnknown84(4)<h4>Background</h4>Psoriasis is associated with increased cardiovascular risk that is not captured by traditional proinflammatory biomarkers.<h4>Objective</h4>To investigate the relationship between Psoriasis Area and Severity Index, circulating proinflammatory biomarkers, and vascular health in psoriasis.<h4>Methods</h4>In patients with psoriasis and in age and sex-matched controls, 273 proteins were analyzed with the Proseek Multiplex Cardiovascular disease reagents kit and Inflammatory reagents kit (Olink Bioscience), whereas vascular endothelial inflammation and health were measured via direct transcriptomic analysis of brachial vein endothelial cells.<h4>Results</h4>In psoriasis, chemokine ligand 20 (CCL20), interleukin (IL) 6, and IL-17A were the top 3 circulating proinflammatory cytJournal of the American Academy of DermatologyCCL20 in psoriasis: A potential biomarker of disease severity, inflammation, and impaired vascular health.PMC8049184UL1 TR000040L30 HL143703R01 HL139909R35 HL144993UL1 TR001445UL1 TR000038R01 HL114978KL2 TR001446T32 HL098129K23 HL152013KL2 TR000053T32 HL007343TL1 TR001447R01 AR074500Scher JUElnabawi YALo Sicco KTawil MKrueger JGarshick MSBarrett TJNeimann ALBerger JSFisher EAfalseCCL20 in psoriasis: A potential biomarker of disease severity, inflammation, and impaired vascular health.<h4>Background</h4>Psoriasis is associated with increased cardiovascular risk that is not captured by traditional proinflammatory biomarkers.<h4>Objective</h4>To investigate the relationship between Psoriasis Area and Severity Index, circulating proinflammatory biomarkers, and vascular health in psoriasis.<h4>Methods</h4>In patients with psoriasis and in age and sex-matched controls, 273 proteins were analyzed with the Proseek Multiplex Cardiovascular disease reagents kit and Inflammatory reagents kit (Olink Bioscience), whereas vascular endothelial inflammation and health were measured via direct transcriptomic analysis of brachial vein endothelial cells.<h4>Results</h4>In psoriasis, chemokine ligand 20 (CCL20), interleukin (IL) 6, and IL-17A were the top 3 circulating proinflammatory cyt2021-01-01T00:00:00Z2021 Apr2025-04-29T11:28:06.293Z2025-04-29T11:28:06.293ZS-EPMC80491843325987610.1016/j.jaad.2020.10.094