{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cichy A"],"funding":["Deutsche Forschungsgemeinschaft","NIDCD NIH HHS","NIDCD","NIH"],"pagination":["2687-2697.e4"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8049193"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(16)"],"pubmed_abstract":["The mammalian main olfactory pathway detects myriad volatile chemicals using >1,000 odorant receptor (OR) genes, which are organized into two phylogenetically distinct classes (class I and class II). An important question is how these evolutionarily conserved classes contribute to odor perception. Here, we report functional inactivation of a large number of class I ORs in mice via identification and deletion of a local cis-acting enhancer in the class I gene cluster. This manipulation reduced expression of half of the 131 intact class I genes. The resulting class I-depleted mice exhibited a significant reduction in the number of glomeruli responding to carboxylic acids-chemicals associated with microbial action and body odors. These mice also exhibit a change in odor perception marked by a"],"journal":["Current biology : CB"],"pubmed_title":["Genetic Depletion of Class I Odorant Receptors Impacts Perception of Carboxylic Acids."],"pmcid":["PMC8049193"],"funding_grant_id":["R01DC013576","F32 DC000357","R03 DC014565","R01 DC013576","R03DC014565","CI 222/1-1"],"pubmed_authors":["Shah A","Cichy A","Bozza T","Dewan A","Kaye S"],"additional_accession":[]},"is_claimable":false,"name":"Genetic Depletion of Class I Odorant Receptors Impacts Perception of Carboxylic Acids.","description":"The mammalian main olfactory pathway detects myriad volatile chemicals using >1,000 odorant receptor (OR) genes, which are organized into two phylogenetically distinct classes (class I and class II). An important question is how these evolutionarily conserved classes contribute to odor perception. Here, we report functional inactivation of a large number of class I ORs in mice via identification and deletion of a local cis-acting enhancer in the class I gene cluster. This manipulation reduced expression of half of the 131 intact class I genes. The resulting class I-depleted mice exhibited a significant reduction in the number of glomeruli responding to carboxylic acids-chemicals associated with microbial action and body odors. These mice also exhibit a change in odor perception marked by a","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2025-04-29T10:19:51.855Z","creation":"2022-02-09T15:56:17.724Z"},"accession":"S-EPMC8049193","cross_references":{"pubmed":["31378611"],"doi":["10.1016/j.cub.2019.06.085"]}}