biostudies-literatureDiao Sthe Disciplines of Excellence-Clinical Research Incubation Project, West China Hospital, Sichuan UniversityProject of Sichuan Provincial Health Commission on breast cancer among urban womenNational Natural Science Foundation of China8230https://www.ebi.ac.uk/biostudies/studies/S-EPMC8050206biostudies-literatureUnknown11(1)There is strong evidence to suggest that obesity-related proteins play a key role in pathways that are related to breast cancer. In this study, we aimed to establish a robust obesity-related protein score (ORPS) that could be used to assess breast cancer risk. Based on evidence from high-quality systematic reviews and population studies, we selected nine such proteins that are stable in vitro, and measured their circulating concentrations by ELISA in a case-control study conducted in Chengdu, Sichuan, China, with 279 breast cancer cases and 260 healthy controls. Two obesity-related protein scores (ORPS) were calculated using a three-step method, with linear-weighted summation, and the one with a larger area under the curve was chosen for further evaluation. As a result, ORPS (PS_5pre or PS_4post) was positively correlated with breast cancer risk (premenopausal: OR_{≤63 VS >63} 3.696, 95% CI 2.025-6.747; postmenopausal: OR_{≤38 VS >38} 7.100, 95% CI 3.134-16.084), and represented a better risk predictor among obese women compared to non-obese in pre- and postmenopausal women. Among different molecular subtypes, ORPS was positively correlated with Luminal breast cancer, with additionally positive association with triple-negative breast cancer in premenopausal women. The ORPS might be a potential marker of breast cancer risk among Chinese women.Scientific reportsObesity-related proteins score as a potential marker of breast cancer risk.PMC8050206No. 2020HXFH009No. 20PJ093No. 81874282Li XTian LLi JXu BZhang XDiao SMiao YHao YYe FWu XZhao XfalseObesity-related proteins score as a potential marker of breast cancer risk.There is strong evidence to suggest that obesity-related proteins play a key role in pathways that are related to breast cancer. In this study, we aimed to establish a robust obesity-related protein score (ORPS) that could be used to assess breast cancer risk. Based on evidence from high-quality systematic reviews and population studies, we selected nine such proteins that are stable in vitro, and measured their circulating concentrations by ELISA in a case-control study conducted in Chengdu, Sichuan, China, with 279 breast cancer cases and 260 healthy controls. Two obesity-related protein scores (ORPS) were calculated using a three-step method, with linear-weighted summation, and the one with a larger area under the curve was chosen for further evaluation. As a result, ORPS (PS_5pre or PS_4post) was positively correlated with breast cancer risk (premenopausal: OR_{≤63 VS >63} 3.696, 95% CI 2.025-6.747; postmenopausal: OR_{≤38 VS >38} 7.100, 95% CI 3.134-16.084), and represented a better risk predictor among obese women compared to non-obese in pre- and postmenopausal women. Among different molecular subtypes, ORPS was positively correlated with Luminal breast cancer, with additionally positive association with triple-negative breast cancer in premenopausal women. The ORPS might be a potential marker of breast cancer risk among Chinese women.2021-01-01T00:00:00Z2021 Apr2026-05-08T06:16:12.272Z2022-02-09T15:55:33.159ZS-EPMC80502063385924410.1038/s41598-021-87583-3