{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Adhyapok P"],"funding":["National Institutes of Health"],"pagination":["102317"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8050378"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(4)"],"pubmed_abstract":["Somitogenesis is often described using the clock-and-wavefront (CW) model, which does not explain how molecular signaling rearranges the pre-somitic mesoderm (PSM) cells into somites. Our scanning electron microscopy analysis of chicken embryos reveals a caudally-progressing epithelialization front in the dorsal PSM that precedes somite formation. Signs of apical constriction and tissue segmentation appear in this layer 3-4 somite lengths caudal to the last-formed somite. We propose a mechanical instability model in which a steady increase of apical contractility leads to periodic failure of adhesion junctions within the dorsal PSM and positions the future inter-somite boundaries. This model produces spatially periodic segments whose size depends on the speed of the activation front of contraction (<i>F</i>), and the buildup rate of contractility (Λ). The Λ/<i>F</i> ratio determines whether this mechanism produces spatially and temporally regular or irregular segments, and whether segment size increases with the front speed."],"journal":["iScience"],"pubmed_title":["A mechanical model of early somite segmentation."],"pmcid":["PMC8050378"],"funding_grant_id":["U01 GM111243","R01 GM076992","R01 GM077138"],"pubmed_authors":["Clendenon SG","Piatkowska AM","Stern CD","Belmonte JM","Norman MJ","Glazier JA","Adhyapok P"],"additional_accession":[]},"is_claimable":false,"name":"A mechanical model of early somite segmentation.","description":"Somitogenesis is often described using the clock-and-wavefront (CW) model, which does not explain how molecular signaling rearranges the pre-somitic mesoderm (PSM) cells into somites. Our scanning electron microscopy analysis of chicken embryos reveals a caudally-progressing epithelialization front in the dorsal PSM that precedes somite formation. Signs of apical constriction and tissue segmentation appear in this layer 3-4 somite lengths caudal to the last-formed somite. We propose a mechanical instability model in which a steady increase of apical contractility leads to periodic failure of adhesion junctions within the dorsal PSM and positions the future inter-somite boundaries. This model produces spatially periodic segments whose size depends on the speed of the activation front of contraction (<i>F</i>), and the buildup rate of contractility (Λ). The Λ/<i>F</i> ratio determines whether this mechanism produces spatially and temporally regular or irregular segments, and whether segment size increases with the front speed.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2024-11-15T19:54:42.044Z","creation":"2022-02-09T15:56:46.059Z"},"accession":"S-EPMC8050378","cross_references":{"pubmed":["33889816"],"doi":["10.1016/j.isci.2021.102317"]}}