{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fang Y"],"funding":["the Bureau of Shunde District Science and Technology under Grant","NICHD NIH HHS","Guangdong Provincial Department of Science and Technology under Grant","the National Institutes of Health (R01HD094381), and the New York State Office of People With Developmental Disabilities"],"pagination":["154"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8051067"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["Background
During intrauterine development, the formation and function of synaptic vesicles (SVs) are thought to be fundamental conditions essential for normal development of the brain. Lacking advanced technology during the intrauterine period, such as longitudinal real-time monitoring of the SV-associated transcripts (SVATs), which include six pairs of lncRNA-mRNA, has limited acquisition of the dynamic gene expression profile (GEP) of SVATs. We previously reported the differential expression of SVATs in the peripheral blood of autistic children. The current study was designed to determine the dynamic profiles of differentially-expressed SVATs in circulating exosomes (EXs) derived from autistic children and pregnant women at different gestational ages.Methods
Blood sample"],"journal":["Journal of translational medicine"],"pubmed_title":["Autism-associated synaptic vesicle transcripts are differentially expressed in maternal plasma exosomes of physiopathologic pregnancies."],"pmcid":["PMC8051067"],"funding_grant_id":["2015CXDT06","OPWDD","2015B050501006","R01 HD094381"],"pubmed_authors":["Fang Y","Wan C","Wen Y","Zhong N","Wu Z","Pan J","Zhong M"],"additional_accession":[]},"is_claimable":false,"name":"Autism-associated synaptic vesicle transcripts are differentially expressed in maternal plasma exosomes of physiopathologic pregnancies.","description":"Background
During intrauterine development, the formation and function of synaptic vesicles (SVs) are thought to be fundamental conditions essential for normal development of the brain. Lacking advanced technology during the intrauterine period, such as longitudinal real-time monitoring of the SV-associated transcripts (SVATs), which include six pairs of lncRNA-mRNA, has limited acquisition of the dynamic gene expression profile (GEP) of SVATs. We previously reported the differential expression of SVATs in the peripheral blood of autistic children. The current study was designed to determine the dynamic profiles of differentially-expressed SVATs in circulating exosomes (EXs) derived from autistic children and pregnant women at different gestational ages.Methods
Blood sample","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-18T13:21:15.868Z","creation":"2022-02-09T15:55:14.614Z"},"accession":"S-EPMC8051067","cross_references":{"pubmed":["33858444"],"doi":["10.1186/s12967-021-02821-6"]}}