{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang S"],"funding":["National Eczema Association","NINDS NIH HHS","National Institutes of Health","NIAMS NIH HHS","NIH HHS"],"pagination":["2151-2166.e16"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8052305"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["184(8)"],"pubmed_abstract":["Cutaneous mast cells mediate numerous skin inflammatory processes and have anatomical and functional associations with sensory afferent neurons. We reveal that epidermal nerve endings from a subset of sensory nonpeptidergic neurons expressing MrgprD are reduced by the absence of Langerhans cells. Loss of epidermal innervation or ablation of MrgprD-expressing neurons increased expression of a mast cell gene module, including the activating receptor, Mrgprb2, resulting in increased mast cell degranulation and cutaneous inflammation in multiple disease models. Agonism of MrgprD-expressing neurons reduced expression of module genes and suppressed mast cell responses. MrgprD-expressing neurons released glutamate which was increased by MrgprD agonism. Inhibiting glutamate release or glutamate re"],"journal":["Cell"],"pubmed_title":["Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis."],"pmcid":["PMC8052305"],"funding_grant_id":["S10 OD011925","R01 AR077341","R01 NS096705","R01 AR069951","R01 AR071720"],"pubmed_authors":["Wu J","Albers KM","Chaudhri VK","Schmitz EG","Koerber HR","Kaplan DH","Zhang S","Hirai T","Davis BM","Cohen JA","Edwards TN","Zhou PY","Poholek AC","McNeil BD","Singh H","Yang Y","Rittenhouse N","Sumpter TL"],"additional_accession":[]},"is_claimable":false,"name":"Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis.","description":"Cutaneous mast cells mediate numerous skin inflammatory processes and have anatomical and functional associations with sensory afferent neurons. We reveal that epidermal nerve endings from a subset of sensory nonpeptidergic neurons expressing MrgprD are reduced by the absence of Langerhans cells. Loss of epidermal innervation or ablation of MrgprD-expressing neurons increased expression of a mast cell gene module, including the activating receptor, Mrgprb2, resulting in increased mast cell degranulation and cutaneous inflammation in multiple disease models. Agonism of MrgprD-expressing neurons reduced expression of module genes and suppressed mast cell responses. MrgprD-expressing neurons released glutamate which was increased by MrgprD agonism. Inhibiting glutamate release or glutamate re","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-29T11:28:06.289Z","creation":"2025-04-06T19:54:56.358Z"},"accession":"S-EPMC8052305","cross_references":{"pubmed":["33765440"],"doi":["10.1016/j.cell.2021.03.002"]}}