{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ullman AJ"],"funding":["National Health and Medical Research Council"],"pagination":["e042475"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8054085"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(4)"],"pubmed_abstract":["<h4>Introduction</h4>Peripherally inserted central catheters (PICCs) are vital for the delivery of medical therapies, but up to 30% of PICCs are associated with complications such as deep vein thrombosis or infection. The integration of antimicrobial and hydrophobic catheter materials, and pressure-activated valves, into polyurethane PICCs are innovations designed to prevent infective and/or thrombotic complications.<h4>Methods and analysis</h4>A multicentre, parallel group, superiority randomised controlled trial with two experimental arms ((1) hydrophobic PICC (with pressure-activated valve); (2) chlorhexidine gluconate-impregnated PICC (with external clamp)) and one control group ((3) conventional polyurethane PICC (with external clamp)). Recruitment of 1098 adult and paediatric patient"],"journal":["BMJ open"],"pubmed_title":["Peripherally Inserted Central catheter iNnovation to reduce Infections and Clots (the PICNIC trial): a randomised controlled trial protocol."],"pmcid":["PMC8054085"],"funding_grant_id":["APP1157178"],"pubmed_authors":["Southam K","Bulmer A","Pearch B","Ullman AJ","August D","Mollee P","Walker R","Runnegar N","Chopra V","Gibson V","Byrnes J","Marsh NM","Kleidon T","Lee-Archer P","Coulthard A","Schults JA","Harris PNA","Rickard CM","Ware RS","Leema J","Biles C"],"additional_accession":[]},"is_claimable":false,"name":"Peripherally Inserted Central catheter iNnovation to reduce Infections and Clots (the PICNIC trial): a randomised controlled trial protocol.","description":"<h4>Introduction</h4>Peripherally inserted central catheters (PICCs) are vital for the delivery of medical therapies, but up to 30% of PICCs are associated with complications such as deep vein thrombosis or infection. The integration of antimicrobial and hydrophobic catheter materials, and pressure-activated valves, into polyurethane PICCs are innovations designed to prevent infective and/or thrombotic complications.<h4>Methods and analysis</h4>A multicentre, parallel group, superiority randomised controlled trial with two experimental arms ((1) hydrophobic PICC (with pressure-activated valve); (2) chlorhexidine gluconate-impregnated PICC (with external clamp)) and one control group ((3) conventional polyurethane PICC (with external clamp)). Recruitment of 1098 adult and paediatric patient","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2026-07-16T06:09:49.454Z","creation":"2022-02-09T17:48:34.038Z"},"accession":"S-EPMC8054085","cross_references":{"pubmed":["33853797"],"doi":["10.1136/bmjopen-2020-042475"]}}