biostudies-literatureUllman AJNational Health and Medical Research Councile042475https://www.ebi.ac.uk/biostudies/studies/S-EPMC8054085biostudies-literatureUnknown11(4)<h4>Introduction</h4>Peripherally inserted central catheters (PICCs) are vital for the delivery of medical therapies, but up to 30% of PICCs are associated with complications such as deep vein thrombosis or infection. The integration of antimicrobial and hydrophobic catheter materials, and pressure-activated valves, into polyurethane PICCs are innovations designed to prevent infective and/or thrombotic complications.<h4>Methods and analysis</h4>A multicentre, parallel group, superiority randomised controlled trial with two experimental arms ((1) hydrophobic PICC (with pressure-activated valve); (2) chlorhexidine gluconate-impregnated PICC (with external clamp)) and one control group ((3) conventional polyurethane PICC (with external clamp)). Recruitment of 1098 adult and paediatric patientBMJ openPeripherally Inserted Central catheter iNnovation to reduce Infections and Clots (the PICNIC trial): a randomised controlled trial protocol.PMC8054085APP1157178Southam KBulmer APearch BUllman AJAugust DMollee PWalker RRunnegar NChopra VGibson VByrnes JMarsh NMKleidon TLee-Archer PCoulthard ASchults JAHarris PNARickard CMWare RSLeema JBiles CfalsePeripherally Inserted Central catheter iNnovation to reduce Infections and Clots (the PICNIC trial): a randomised controlled trial protocol.<h4>Introduction</h4>Peripherally inserted central catheters (PICCs) are vital for the delivery of medical therapies, but up to 30% of PICCs are associated with complications such as deep vein thrombosis or infection. The integration of antimicrobial and hydrophobic catheter materials, and pressure-activated valves, into polyurethane PICCs are innovations designed to prevent infective and/or thrombotic complications.<h4>Methods and analysis</h4>A multicentre, parallel group, superiority randomised controlled trial with two experimental arms ((1) hydrophobic PICC (with pressure-activated valve); (2) chlorhexidine gluconate-impregnated PICC (with external clamp)) and one control group ((3) conventional polyurethane PICC (with external clamp)). Recruitment of 1098 adult and paediatric patient2021-01-01T00:00:00Z2021 Apr2026-07-16T06:09:49.454Z2022-02-09T17:48:34.038ZS-EPMC80540853385379710.1136/bmjopen-2020-042475