{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schindler SE"],"funding":["NIA NIH HHS"],"pagination":["e571"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8054965"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(2)"],"pubmed_abstract":["<h4>Objective</h4>To evaluate for racial differences in triggering receptor expressed on myeloid cells 2 (TREM2), a key immune mediator in Alzheimer disease, the levels of CSF soluble TREM2 (sTREM2), and the frequency of associated genetic variants were compared in groups of individuals who self-reported their race as African American (AA) or non-Hispanic White (NHW).<h4>Methods</h4>Community-dwelling older research participants underwent measurement of CSF sTREM2 concentrations and genetic analyses.<h4>Results</h4>The primary cohort included 91 AAs and 868 NHWs. CSF sTREM2 levels were lower in the AA compared with the NHW group (1,336 ± 470 vs 1,856 ± 624 pg/mL, <i>p</i> < 0.0001). AAs were more likely to carry <i>TREM2</i> coding variants (15% vs 3%, <i>p</i> < 0.0001), which were associ"],"journal":["Neurology. Genetics"],"pubmed_title":["African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants."],"pmcid":["PMC8054965"],"funding_grant_id":["R01 AG070941","P30 AG066444","RF1 AG071706","R03 AG050921","U01 AG024904","P50 AG005681","P01 AG026276","K23 AG053426","T32 AG000213","P01 AG003991"],"pubmed_authors":["Llibre-Guerra JJ","Farias FHG","Fagan AM","Holtzman DM","Ances BM","Piccio L","Morris JC","Deming Y","Schindler SE","Cruchaga C","Mikesell RJ","Henson RL","Wilkins CH","Xiong C","Joseph A","Moulder KL","Benzinger TLS","McCue L"],"additional_accession":[]},"is_claimable":false,"name":"African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants.","description":"<h4>Objective</h4>To evaluate for racial differences in triggering receptor expressed on myeloid cells 2 (TREM2), a key immune mediator in Alzheimer disease, the levels of CSF soluble TREM2 (sTREM2), and the frequency of associated genetic variants were compared in groups of individuals who self-reported their race as African American (AA) or non-Hispanic White (NHW).<h4>Methods</h4>Community-dwelling older research participants underwent measurement of CSF sTREM2 concentrations and genetic analyses.<h4>Results</h4>The primary cohort included 91 AAs and 868 NHWs. CSF sTREM2 levels were lower in the AA compared with the NHW group (1,336 ± 470 vs 1,856 ± 624 pg/mL, <i>p</i> < 0.0001). AAs were more likely to carry <i>TREM2</i> coding variants (15% vs 3%, <i>p</i> < 0.0001), which were associ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-22T00:37:37.556Z","creation":"2022-02-10T09:25:22.836Z"},"accession":"S-EPMC8054965","cross_references":{"pubmed":["33884297"],"doi":["10.1212/NXG.0000000000000571"]}}