biostudies-literatureSchindler SENIA NIH HHSe571https://www.ebi.ac.uk/biostudies/studies/S-EPMC8054965biostudies-literatureUnknown7(2)<h4>Objective</h4>To evaluate for racial differences in triggering receptor expressed on myeloid cells 2 (TREM2), a key immune mediator in Alzheimer disease, the levels of CSF soluble TREM2 (sTREM2), and the frequency of associated genetic variants were compared in groups of individuals who self-reported their race as African American (AA) or non-Hispanic White (NHW).<h4>Methods</h4>Community-dwelling older research participants underwent measurement of CSF sTREM2 concentrations and genetic analyses.<h4>Results</h4>The primary cohort included 91 AAs and 868 NHWs. CSF sTREM2 levels were lower in the AA compared with the NHW group (1,336 ± 470 vs 1,856 ± 624 pg/mL, <i>p</i> < 0.0001). AAs were more likely to carry <i>TREM2</i> coding variants (15% vs 3%, <i>p</i> < 0.0001), which were associNeurology. GeneticsAfrican Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants.PMC8054965R01 AG070941P30 AG066444RF1 AG071706R03 AG050921U01 AG024904P50 AG005681P01 AG026276K23 AG053426T32 AG000213P01 AG003991Llibre-Guerra JJFarias FHGFagan AMHoltzman DMAnces BMPiccio LMorris JCDeming YSchindler SECruchaga CMikesell RJHenson RLWilkins CHXiong CJoseph AMoulder KLBenzinger TLSMcCue LfalseAfrican Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants.<h4>Objective</h4>To evaluate for racial differences in triggering receptor expressed on myeloid cells 2 (TREM2), a key immune mediator in Alzheimer disease, the levels of CSF soluble TREM2 (sTREM2), and the frequency of associated genetic variants were compared in groups of individuals who self-reported their race as African American (AA) or non-Hispanic White (NHW).<h4>Methods</h4>Community-dwelling older research participants underwent measurement of CSF sTREM2 concentrations and genetic analyses.<h4>Results</h4>The primary cohort included 91 AAs and 868 NHWs. CSF sTREM2 levels were lower in the AA compared with the NHW group (1,336 ± 470 vs 1,856 ± 624 pg/mL, <i>p</i> < 0.0001). AAs were more likely to carry <i>TREM2</i> coding variants (15% vs 3%, <i>p</i> < 0.0001), which were associ2021-01-01T00:00:00Z2021 Apr2025-04-22T00:37:37.556Z2022-02-10T09:25:22.836ZS-EPMC80549653388429710.1212/NXG.0000000000000571