{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["29(4)"],"submitter":["Li Y"],"funding":["National Natural Science Foundation of China"],"pubmed_abstract":["Pulmonary artery smooth muscle cells (PASMCs) proliferation caused by hypoxia is an important pathological process of pulmonary hypertension (PH). Prevention of PASMCs proliferation can effectively reduce PH mortality. Long non-coding RNAs (lncRNAs) are involved in the proliferation process. Recent evidence has demonstrated that functional peptides encoded by lncRNAs play important roles in cell pathophysiological process. Our previous study has demonstrated that lnc-Rps4l with high coding ability mediates the PASMCs proliferation under hypoxic conditions. We hypothesize in this study that a lnc-Rps4l-encoded peptide is involved in hypoxic-induced PASMCs proliferation. The presence of peptide 40S ribosomal protein S4 X isoform-like (RPS4XL) encoded by lnc-Rps4l in PASMCs under hypoxic cond"],"journal":["Molecular therapy : the journal of the American Society of Gene Therapy"],"pagination":["1411-1424"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8058491"],"repository":["biostudies-literature"],"pubmed_title":["lnc-Rps4l-encoded peptide RPS4XL regulates RPS6 phosphorylation and inhibits the proliferation of PASMCs caused by hypoxia."],"pmcid":["PMC8058491"],"pubmed_authors":["Yang J","Zhang J","Shi W","Wang G","Zhang L","Zhu D","Zhao X","Li W","Jiang Y","Li Y","Chen Y","Sun H","Xin W","Yu X"],"additional_accession":[]},"is_claimable":false,"name":"lnc-Rps4l-encoded peptide RPS4XL regulates RPS6 phosphorylation and inhibits the proliferation of PASMCs caused by hypoxia.","description":"Pulmonary artery smooth muscle cells (PASMCs) proliferation caused by hypoxia is an important pathological process of pulmonary hypertension (PH). Prevention of PASMCs proliferation can effectively reduce PH mortality. Long non-coding RNAs (lncRNAs) are involved in the proliferation process. Recent evidence has demonstrated that functional peptides encoded by lncRNAs play important roles in cell pathophysiological process. Our previous study has demonstrated that lnc-Rps4l with high coding ability mediates the PASMCs proliferation under hypoxic conditions. We hypothesize in this study that a lnc-Rps4l-encoded peptide is involved in hypoxic-induced PASMCs proliferation. The presence of peptide 40S ribosomal protein S4 X isoform-like (RPS4XL) encoded by lnc-Rps4l in PASMCs under hypoxic cond","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2026-05-31T13:02:04.767Z","creation":"2025-04-06T21:48:53.177Z"},"accession":"S-EPMC8058491","cross_references":{"pubmed":["33429084"],"doi":["10.1016/j.ymthe.2021.01.005"]}}