{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kurzawa N"],"funding":["lowship of the EMBL International Postdoc programme","European Molecular Biology Laboratory","Marie Skłodowska","EMBL International PhD programme"],"pagination":["431-433"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8058776"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["37(3)"],"pubmed_abstract":["<h4>Summary</h4>Rtpca is an R package implementing methods for inferring protein-protein interactions (PPIs) based on thermal proteome profiling experiments of a single condition or in a differential setting via an approach called thermal proximity coaggregation. It offers user-friendly tools to explore datasets for their PPI predictive performance and easily integrates with available R packages.<h4>Availability and implementation</h4>Rtpca is available from Bioconductor (https://bioconductor.org/packages/Rtpca).<h4>Supplementary information</h4>Supplementary data are available at Bioinformatics online."],"journal":["Bioinformatics (Oxford, England)"],"pubmed_title":["Rtpca: an R package for differential thermal proximity coaggregation analysis."],"pmcid":["PMC8058776"],"funding_grant_id":["664726"],"pubmed_authors":["Savitski MM","Mateus A","Kurzawa N"],"additional_accession":[]},"is_claimable":false,"name":"Rtpca: an R package for differential thermal proximity coaggregation analysis.","description":"<h4>Summary</h4>Rtpca is an R package implementing methods for inferring protein-protein interactions (PPIs) based on thermal proteome profiling experiments of a single condition or in a differential setting via an approach called thermal proximity coaggregation. It offers user-friendly tools to explore datasets for their PPI predictive performance and easily integrates with available R packages.<h4>Availability and implementation</h4>Rtpca is available from Bioconductor (https://bioconductor.org/packages/Rtpca).<h4>Supplementary information</h4>Supplementary data are available at Bioinformatics online.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-05-31T22:20:47.148Z","creation":"2022-02-09T17:48:36.607Z"},"accession":"S-EPMC8058776","cross_references":{"pubmed":["32717044"],"doi":["10.1093/bioinformatics/btaa682"]}}