biostudies-literatureKurzawa Nlowship of the EMBL International Postdoc programmeEuropean Molecular Biology LaboratoryMarie SkłodowskaEMBL International PhD programme431-433https://www.ebi.ac.uk/biostudies/studies/S-EPMC8058776biostudies-literatureUnknown37(3)<h4>Summary</h4>Rtpca is an R package implementing methods for inferring protein-protein interactions (PPIs) based on thermal proteome profiling experiments of a single condition or in a differential setting via an approach called thermal proximity coaggregation. It offers user-friendly tools to explore datasets for their PPI predictive performance and easily integrates with available R packages.<h4>Availability and implementation</h4>Rtpca is available from Bioconductor (https://bioconductor.org/packages/Rtpca).<h4>Supplementary information</h4>Supplementary data are available at Bioinformatics online.Bioinformatics (Oxford, England)Rtpca: an R package for differential thermal proximity coaggregation analysis.PMC8058776664726Savitski MMMateus AKurzawa NfalseRtpca: an R package for differential thermal proximity coaggregation analysis.<h4>Summary</h4>Rtpca is an R package implementing methods for inferring protein-protein interactions (PPIs) based on thermal proteome profiling experiments of a single condition or in a differential setting via an approach called thermal proximity coaggregation. It offers user-friendly tools to explore datasets for their PPI predictive performance and easily integrates with available R packages.<h4>Availability and implementation</h4>Rtpca is available from Bioconductor (https://bioconductor.org/packages/Rtpca).<h4>Supplementary information</h4>Supplementary data are available at Bioinformatics online.2021-01-01T00:00:00Z2021 Apr2025-05-31T22:20:47.148Z2022-02-09T17:48:36.607ZS-EPMC80587763271704410.1093/bioinformatics/btaa682