biostudies-literatureKelly SHNational Institute of Allergy and Infectious DiseasesNIBIB NIH HHSNIAID NIH HHSNational Institutes of HealthNorth Carolina Biotechnology CenterNational Institute of Biomedical Imaging and BioengineeringNational Science Foundatione2001614https://www.ebi.ac.uk/biostudies/studies/S-EPMC8059599biostudies-literatureUnknown10(6)Widespread vaccination is essential to global health. Significant barriers exist to improving vaccine coverage in lower- and middle-income countries, including the costly requirements for cold-chain distribution and trained medical personnel to administer the vaccines. A heat-stable and highly porous tablet vaccine that can be administered sublingually via simple dissolution under the tongue is described. SIMPL tablet vaccines (Supramolecular IMmunization with Peptides subLingually) are produced by freeze-drying a mixture of self-assembling peptide-polymer nanofibers, sugars, and adjuvant. Sublingual immunization with SIMPL tablets raises antibody responses against both a model epitope from ovalbumin and a clinically relevant epitope from Mycobacterium tuberculosis. Further, sublingual antAdvanced healthcare materialsTabletized Supramolecular Assemblies for Sublingual Peptide Immunization.PMC8059599R01 EB0097015R01EB009701R01 AI1181825R01AI118182Collier JHKelly SHCossette BVaradhan AKWu YOpolot EEfalseTabletized Supramolecular Assemblies for Sublingual Peptide Immunization.Widespread vaccination is essential to global health. Significant barriers exist to improving vaccine coverage in lower- and middle-income countries, including the costly requirements for cold-chain distribution and trained medical personnel to administer the vaccines. A heat-stable and highly porous tablet vaccine that can be administered sublingually via simple dissolution under the tongue is described. SIMPL tablet vaccines (Supramolecular IMmunization with Peptides subLingually) are produced by freeze-drying a mixture of self-assembling peptide-polymer nanofibers, sugars, and adjuvant. Sublingual immunization with SIMPL tablets raises antibody responses against both a model epitope from ovalbumin and a clinically relevant epitope from Mycobacterium tuberculosis. Further, sublingual ant2021-01-01T00:00:00Z2021 Mar2025-04-04T10:16:21.92Z2025-04-04T10:16:21.92ZS-EPMC80595993363460710.1002/adhm.202001614