biostudies-literatureUnknown288(1947)Ziegler FThe bitter taste sensation is important to warn mammals of the ingestion of potentially toxic food compounds. For mammals, whose nutrition relies on highly specific food sources, such as blood in the case of vampire bats, it is unknown if bitter sensing is involved in prey selection. By contrast to other bat species, vampire bats exhibit numerous bitter taste receptor pseudogenes, which could point to a decreased importance of bitter taste. However, electrophysiological and behavioural studies suggest the existence of functional bitter taste transmission. To determine the agonist spectra of the three bitter taste receptors that are conserved in all three vampire bat species, we investigated the <i>in vitro</i> activation of <i>Desmodus rotundus</i> T2R1, T2R4 and T2R7. Using a set of 57 naProceedings. Biological sciences20210418https://www.ebi.ac.uk/biostudies/studies/S-EPMC8059964biostudies-literatureBitter taste receptors of the common vampire bat are functional and show conserved responses to metal ions <i>in vitro</i>.PMC8059964Behrens MZiegler FfalseBitter taste receptors of the common vampire bat are functional and show conserved responses to metal ions <i>in vitro</i>.The bitter taste sensation is important to warn mammals of the ingestion of potentially toxic food compounds. For mammals, whose nutrition relies on highly specific food sources, such as blood in the case of vampire bats, it is unknown if bitter sensing is involved in prey selection. By contrast to other bat species, vampire bats exhibit numerous bitter taste receptor pseudogenes, which could point to a decreased importance of bitter taste. However, electrophysiological and behavioural studies suggest the existence of functional bitter taste transmission. To determine the agonist spectra of the three bitter taste receptors that are conserved in all three vampire bat species, we investigated the <i>in vitro</i> activation of <i>Desmodus rotundus</i> T2R1, T2R4 and T2R7. Using a set of 57 na2021-01-01T00:00:00Z2021 Mar2025-04-29T11:27:12.173Z2025-04-29T11:27:12.173ZS-EPMC80599643378486710.1098/rspb.2021.0418